Publication Name	World Journal of Experimental Medicine
Manuscript ID	108984
Country	Russia

Category	Oncology
Manuscript Type	Observational Study
Article Title	Concordance of programmed death-ligand 1 expression assessments determined via two immunohistochemical tests and the polymerase chain reaction method
Manuscript Source	Invited Manuscript
All Author List	Marina A Senchukova, Natalia V Saidler, Evgeniya Yu Zubareva, Alexander B Prokofiev and Dmitry G Tagabilev
Funding Agency and Grant Number	Funding Agency Grant Number Russian Science Foundation No. 23-25-00183
Corresponding Author	Marina A Senchukova, MD, PhD, Professor, Scientific and Clinical Center No. 3, Petrovsky National Research Centre of Surgery, Oktyabrsky Prospekt 3, Moscow 108840, Troitsk, Russia. masenchukova@yandex.com
Key Words	Breast cancer; Cohen kappa index; Negative percentage agreement; Positive percentage agreement; Programmed death-ligand 1; Programmed cell death protein 1 ligand 1
Core Tip	We determined the expression of programmed cell death ligand 1 in immune cells using immunohistochemistry with antibodies against programmed cell death protein 1 ligand 1 (PDCD1 LG1) and SP142 and polymerase chain reaction (PCR) and then examined the agreement between the results of three assays in patients with breast cancer (BC). All three tests were positively correlated with estrogen receptor-negative status, human epidermal growth factor receptor-2-positive (HER2+) status, and luminal B HER+, nonluminal HER+, and triple-negative BCs. Cohen's kappa index was 0.385 for PDCD1 LG1 and SP142 and 0.389 for SP142 and programmed death-ligand 1 (PCR), which is considered moderate agreement between the markers.
Citation	<p>Senchukova MA, Saidler NV, Zubareva EY, Prokofiev AB, Tagabilev DG. Concordance of programmed death-ligand 1 expression assessments determined via two immunohistochemical tests and the polymerase chain reaction method. <i>World J Exp Med</i> 2025; 15(3): 108984</p>

Received	2025-04-27 15:35
Peer-Review Started	2025-05-04 01:31
To Make the First Decision
Return for Revision	2025-05-14 03:21
Revised	2025-05-21 09:33
Second Decision	2025-07-28 02:38
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-29 10:40
Articles in Press	2025-07-29 10:40
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-08-01 05:36

ISSN	2220-315x (online)
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