Publication Name	World Journal of Orthopedics
Manuscript ID	108992
Country	Japan

Category	Orthopedics
Manuscript Type	Review
Article Title	Early diagnosis and targeted intervention based on the pathogenesis of rapidly progressive osteoarthritis of the hip
Manuscript Source	Invited Manuscript
All Author List	Tadashi Yasuda
Funding Agency and Grant Number
Corresponding Author	Tadashi Yasuda, MD, PhD, Department of Orthopaedic Surgery, Kobe City Medical Center General Hospital, 2-1-1 Minatojima-minamimachi, Chuo-ku, Kobe 650-0047, Hyogo, Japan. tadyasu@kcho.jp
Key Words	Rapidly progressive osteoarthritis; Hip joint; Classification; Early diagnosis; Early intervention; Imaging; Matrix metalloproteinase-3; Spinopelvic alignment; Pathophysiology
Core Tip	Disease progression of rapidly progressive hip osteoarthritis in the early stages may be classified into two distinct types: Chondrolysis with or without subsequent femoral head destruction. Serum matrix metalloproteinase-3 levels and spinopelvic malalignment may be predictive factors for subsequent bone destruction when only joint space narrowing is observed. Cartilage matrix fragments generated by stress concentrations on the hip joint due to spinopelvic malalignment may trigger inflammatory pathways involving cytokine and inflammasome activation, resulting in joint destruction during the initial phase of rapidly progressive hip osteoarthritis. A clear understanding of its pathogenesis is essential for early diagnosis and effective intervention.
Citation	Yasuda T. Early diagnosis and targeted intervention based on the pathogenesis of rapidly progressive osteoarthritis of the hip. World J Orthop 2025; In press

Received	2025-04-28 10:59
Peer-Review Started	2025-04-28 10:59
To Make the First Decision
Return for Revision	2025-05-12 05:10
Revised	2025-05-26 03:02
Second Decision	2025-09-04 02:51
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-04 07:37
Articles in Press	2025-09-04 07:37
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-5836 (online)
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