Publication Name	World Journal of Clinical Oncology
Manuscript ID	109034
Country	Italy

Category	Surgery
Manuscript Type	Systematic Reviews
Article Title	Advancing gastric cancer treatment: A comprehensive review of hyperthermic intraperitoneal chemotherapy’s role and outcomes
Manuscript Source	Invited Manuscript
All Author List	Fabrizio D'Acapito, Massimo Framarini, Paolo Morgagni, Daniela Di Pietrantonio, Giovanni Vittimberga, Valentina Zucchini and Giorgio Ercolani
Funding Agency and Grant Number
Corresponding Author	Fabrizio D'Acapito, Consultant, PhD, Department of General and Oncologic Surgery, Morgagni-Pierantoni Hospital, AUSL Romagna, Via Carlo Forlanini 34, Forli 47121, Emilia-Romagna, Italy. fabrizioda@gmail.com
Key Words	Gastric cancer; Peritoneal metastasis; Hyperthermic intraperitoneal chemotherapy; Clinical trial; Outcomes
Core Tip	This systematic review evaluates prospective trials assessing hyperthermic intraperitoneal chemotherapy (HIPEC) in gastric cancer (GC). Therapeutically, HIPEC combined with cytoreductive surgery improves survival in selected patients with peritoneal metastases. Prophylactically, HIPEC reduces peritoneal recurrence after curative gastrectomy in high-risk patients. While promising, outcomes are influenced by heterogeneity in protocols, chemotherapy regimens, and selection criteria. Completeness of cytoreduction remains the strongest predictor of benefit. Future trials should standardize patient selection and HIPEC approaches to clarify its role within multimodal GC treatment strategies.
Citation	D'Acapito F, Framarini M, Morgagni P, Di Pietrantonio D, Vittimberga G, Zucchini V, Ercolani G. Advancing gastric cancer treatment: A comprehensive review of hyperthermic intraperitoneal chemotherapy’s role and outcomes. World J Clin Oncol 2025; In press

Received	2025-04-28 10:17
Peer-Review Started	2025-04-28 10:17
To Make the First Decision
Return for Revision	2025-05-12 10:05
Revised	2025-05-26 00:26
Second Decision	2025-08-08 02:43
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-08-08 08:15
Articles in Press	2025-08-08 08:15
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ISSN	2218-4333 (online)
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