Publication Name	World Journal of Gastrointestinal Endoscopy
Manuscript ID	109104
Country	United Kingdom

Category	Oncology
Manuscript Type	Case Report
Article Title	Isolation techniques for gastrointestinal tract defects: Two case reports
Manuscript Source	Unsolicited Manuscript
All Author List	Aleksei A Kashintsev, Roman Vladimirovich Eselevich, Dmitry Aleksandrovich Surov, Oleg Valeryevich Balyura and Vitali Yu Proutski
Funding Agency and Grant Number
Corresponding Author	Aleksei A Kashintsev, MD, PhD, PANDICA LTD, 22 Great James Street, London WC1N 3ES, United Kingdom. alexey.kashintsev@pandica.com
Key Words	Gastric cancer; Acute pancreatitis; VAC therapy; Anastomotic leakage; Fistulas; Enteral nutrition; Case report
Core Tip	The treatment of gastrointestinal tract defects and fistulas remains a complex challenge without a standardized approach, due to the highly variable and often unique nature of injuries. Our experience highlights a novel method combining isolation of the affected gastrointestinal segment with local vacuum-assisted therapy while maintaining enteral nutrition. This approach not only facilitates early detection and dynamic monitoring of fistulas but also promotes faster healing by preventing contact with gastrointestinal contents and preserving mucosal integrity through continued enteral feeding. By applying this method in oncologic patients undergoing similar surgeries, we demonstrate its feasibility, safety, and potential to significantly improve clinical outcomes. Further exploration of segmental isolation may expand therapeutic options for various abdominal pathologies.
Citation	Kashintsev AA, Eselevich RV, Surov DA, Balyura OV, Proutski V. Isolation techniques for gastrointestinal tract defects: Two case reports. World J Gastrointest Endosc 2025; In press

Received	2025-04-29 03:45
Peer-Review Started	2025-05-04 02:14
To Make the First Decision
Return for Revision	2025-05-22 11:37
Revised	2025-06-03 12:01
Second Decision	2025-06-27 02:39
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-27 08:18
Articles in Press	2025-06-27 08:18
Publication Fee Transferred	2025-06-04 14:14
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5190 (online)
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