Publication Name	World Journal of Orthopedics
Manuscript ID	109149
Country	China

Category	Orthopedics
Manuscript Type	Editorial
Article Title	Advancing bone regeneration: Clinical implications of synthetic biomaterials and fibrin derivatives
Manuscript Source	Invited Manuscript
All Author List	Ren-Xian Xie, Yi-Xuan Xing and Nian-Zhe Sun
Funding Agency and Grant Number
Corresponding Author	Nian-Zhe Sun, MD, Department of Orthopedics, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Kaifu District, Changsha 410008, Hunan Province, China. sunnzh201921@sina.com
Key Words	Biomaterials; Bone regeneration; Fibrin sealant; Hydroxyapatite; Regenerative medicine
Core Tip	The integration of synthetic biomaterials, for example hydroxyapatite and β-tricalcium phosphate, with fibrin derivatives enhances bone regeneration by improving scaffold stability, cellular recruitment, and mechanical support. While promising, clinical adoption requires standardized protocols, long-term outcome validation, and personalized approaches to address complex bone defects in aging and comorbid populations.
Citation	Xie RX, Xing YX, Sun NZ. Advancing bone regeneration: Clinical implications of synthetic biomaterials and fibrin derivatives. World J Orthop 2025; In press

Received	2025-05-06 09:46
Peer-Review Started	2025-05-06 09:46
To Make the First Decision
Return for Revision	2025-06-10 07:14
Revised	2025-06-13 02:26
Second Decision	2025-07-10 02:44
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-10 07:46
Articles in Press	2025-07-10 07:46
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-5836 (online)
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