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Publication Name World Journal of Orthopedics
Manuscript ID 109149
Country China
Category Orthopedics
Manuscript Type Editorial
Article Title Advancing bone regeneration: Clinical implications of synthetic biomaterials and fibrin derivatives
Manuscript Source Invited Manuscript
All Author List Ren-Xian Xie, Yi-Xuan Xing and Nian-Zhe Sun
Funding Agency and Grant Number
Corresponding Author Nian-Zhe Sun, MD, Department of Orthopedics, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Kaifu District, Changsha 410008, Hunan Province, China. sunnzh201921@sina.com
Key Words Biomaterials; Bone regeneration; Fibrin sealant; Hydroxyapatite; Regenerative medicine
Core Tip The integration of synthetic biomaterials, for example hydroxyapatite and β-tricalcium phosphate, with fibrin derivatives enhances bone regeneration by improving scaffold stability, cellular recruitment, and mechanical support. While promising, clinical adoption requires standardized protocols, long-term outcome validation, and personalized approaches to address complex bone defects in aging and comorbid populations.
Citation Xie RX, Xing YX, Sun NZ. Advancing bone regeneration: Clinical implications of synthetic biomaterials and fibrin derivatives. World J Orthop 2025; In press
Received
2025-05-06 09:46
Peer-Review Started
2025-05-06 09:46
To Make the First Decision
Return for Revision
2025-06-10 07:14
Revised
2025-06-13 02:26
Second Decision
2025-07-10 02:44
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief
2025-07-10 07:46
Articles in Press
2025-07-10 07:46
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 2218-5836 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
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