Publication Name	World Journal of Clinical Oncology
Manuscript ID	109182
Country	Türkiye

Category	Oncology
Manuscript Type	Retrospective Study
Article Title	Lynch syndrome association and clinicopathological features in early-onset colorectal cancers: A single-center retrospective study
Manuscript Source	Invited Manuscript
All Author List	Yunus Sür, Emine Özlem Gür, Fevzi Cengiz, Aslı Subaşıoğlu, İsmail Güzeliş, Sinem Demir, Aysegul Akder Sari, Mehmet Haciyanli and Osman Nuri Dilek
Funding Agency and Grant Number
Corresponding Author	Yunus Sür, MD, Department of General Surgery, İKÇÜ Atatürk Education and Research Hospital, Basin Sitesi, İzmir 35150, Türkiye. dr.yunus.sur@gmail.com
Key Words	Mismatch repair; Microsatellite instability; Lynch syndrome; Immunohistochemistry; Early-onset colorectal cancer
Core Tip	Lynch syndrome (LS) results from microsatellite instability (MSI). Immunohistochemistry (IHC) is a cost-effective and practical method for MSI screening. This retrospective study evaluated clinicopathological features of MSI and microsatellite-stable (MSS) tumors in early-onset colorectal cancer patients between 2014 and 2021. MSI tumors were linked to younger age, right-sided location, and fewer metastases. Genetic testing confirmed LS in 76.4% of MSI and 2.8% of MSS cases based on IHC. However, 59.5% of patients did not receive genetic counseling. While IHC is useful for MSI detection, it may not be sufficient alone. Low counseling rates emphasize the need for hospital-based surveillance programs.
Citation	Sür Y, Gür EÖ, Cengiz F, Subaşıoğlu A, Güzeliş İ, Demir S, Sari AA, Haciyanli M, Dilek ON. Lynch syndrome association and clinicopathological features in early-onset colorectal cancers: A single-center retrospective study. World J Clin Oncol 2025; In press

Received	2025-05-06 07:37
Peer-Review Started	2025-05-06 07:37
To Make the First Decision
Return for Revision	2025-05-20 18:55
Revised	2025-05-25 20:35
Second Decision	2025-08-07 02:44
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-08-08 10:25
Articles in Press	2025-08-08 10:25
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ISSN	2218-4333 (online)
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