Publication Name	World Journal of Critical Care Medicine
Manuscript ID	109194
Country	Brazil

Category	Critical Care Medicine
Manuscript Type	Opinion Review
Article Title	Giving urine biochemistry a second chance in acute kidney injury monitoring
Manuscript Source	Unsolicited Manuscript
All Author List	Alexandre Toledo Maciel
Funding Agency and Grant Number
Corresponding Author	Alexandre Toledo Maciel, Head, MD, Department of Research, Imed Group, Hospital São Camilo Pompéia Adult ICU, Pompeia Avenue 1178 4 th floor, São Paulo 05022-001, São Paulo, Brazil. alexandre.toledo@imedgroup.com.br
Key Words	Urine biochemistry; Urine electrolytes; Acute kidney injury; Monitoring; Urine bio-chemical approach; Fractional excretion of potassium; Urinary potassium/urinary cre-atinine concentration ratio; Urinary sodium concentration; Excreted mass of creatinine
Core Tip	The utility of urine biochemistry assessment for acute kidney injury (AKI) monitoring was proposed 50 years ago, being theoretically capable of defining AKI pathophysiol-ogy and distinguishing functional (“pre-renal”) and structural (“renal”) impairments. However, the actual usefulness of urine biochemistry was never confirmed due to vari-able and controversial results among studies. In this review, alternative considerations for when to assess urine electrolytes and how to interpret their values for renal function monitoring are proposed.
Citation	Maciel AT. Giving urine biochemistry a second chance in acute kidney injury monitor-ing. World J Crit Care Med 2025; In press

Received	2025-05-06 06:30
Peer-Review Started	2025-05-06 06:31
To Make the First Decision
Return for Revision	2025-05-14 03:12
Revised	2025-06-04 18:41
Second Decision	2025-07-21 03:00
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-22 01:56
Articles in Press	2025-07-22 01:56
Publication Fee Transferred	2025-06-07 15:53
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3141(online)
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