Publication Name	World Journal of Gastroenterology
Manuscript ID	109235
Country	Egypt

Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Duodenal mucosal ablation with irreversible electroporation in non-alcoholic fatty liver disease: Roadmap of the future treatment
Manuscript Source	Unsolicited Manuscript
All Author List	Khaled Mohamed Mohamed Koriem
Funding Agency and Grant Number
Corresponding Author	Khaled Mohamed Mohamed Koriem, PhD, Professor, Department of Medical Physiology, Medical Research and Clinical Studies Institute, National Research Centre, 33 El-Buhouth Street, Dokki, P.O. Box, Giza 12622, Egypt. kkoriem@yahoo.com
Key Words	Non-alcoholic fatty liver disease; Duodenal mucosal ablation; Irreversible electroporation; Lipid deposition; Endocrine function; Inflammatory markers
Core Tip	The novel work by Yu et al on the feasibility and efficacy of duodenal mucosal ablation (DMA) with irreversible electroporation (IRE) in non-alcoholic fatty liver disease (NAFLD) rodents is thoroughly examined in this article. The duodenum repaired effectively two weeks after DMA with IRE, according to the study in a sophisticated manner. In NAFLD small rats, the detection of liver lipid deposition, serum lipid parameters, and enteroendocrine parameters such claudin and zonula ocludens-1 levels offer new opportunities for side-effects assessment and advanced therapy approaches.
Citation	Koriem KMM. Duodenal mucosal ablation with irreversible electroporation in non-alcoholic fatty liver disease: Roadmap of the future treatment. World J Gastroenterol 2025; In press

Received	2025-05-06 02:56
Peer-Review Started	2025-05-06 02:56
To Make the First Decision
Return for Revision	2025-06-04 02:23
Revised	2025-06-04 14:38
Second Decision	2025-07-30 02:38
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-30 05:09
Articles in Press	2025-07-30 05:09
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-08-05 08:52

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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