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Publication Name World Journal of Gastroenterology
Manuscript ID 109239
Country China
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Translocator protein facilitates neutrophil-mediated mucosal inflammation in inflammatory bowel diseases
Manuscript Source Unsolicited Manuscript
All Author List Qiong He, Xiao-Han Wu, Dong-Lang Jiang, Ri-Tian Lin, Fang Xie, Yi-Hui Guan and Ai-Hua Fei
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China No. 82300604
Science and Technology Innovation Action Plan Star Project Application Guide/Star Project Incubation (Yangfan Special Program) of Shanghai No. 24YF2727600
Corresponding Author Ai-Hua Fei, Chief Physician, Department of General Medicine, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, No. 1665 Kongjiang Road, Yangpu District, Shanghai 200092, China. feiaihua@xinhuamed.com.cn
Key Words Inflammatory bowel disease; Ulcerative colitis; Crohn's disease; Translocator protein; Expression; Neutrophil; Intestinal inflammation; Neuroinflammation; Positron emission tomography-computed tomography; Gut-brain axis
Core Tip This research recognizes translocator protein (TSPO) as a novel biomarker and promising therapeutic target for inflammatory bowel diseases (IBD). Elevated TSPO expression was observed in neutrophils of IBD patients, along with increased reactive oxygen species (ROS) production and neutrophil extracellular trap formation. Additionally, upregulated TSPO in both the inflamed colon and brain tissue suggests its contributions to autoimmune inflammation and neuroinflammation. These findings recommend TSPO as a potential target for IBD treatment, highlighting its role in both intestinal and neurological inflammatory processes.
Citation He Q, Wu XH, Jiang DL, Lin RT, Xie F, Guan YH, Fei AH. Translocator protein facilitates neutrophil-mediated mucosal inflammation in inflammatory bowel diseases. World J Gastroenterol 2025; In press
Received
2025-05-06 10:00
Peer-Review Started
2025-05-06 10:00
To Make the First Decision
Return for Revision
2025-05-16 22:53
Revised
2025-05-28 13:01
Second Decision
2025-06-16 02:41
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief
2025-06-16 06:40
Articles in Press
2025-06-16 06:40
Publication Fee Transferred
2025-05-29 11:05
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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