Publication Name	World Journal of Diabetes
Manuscript ID	109274
Country	Kuwait

Category	Biochemistry & Molecular Biology
Manuscript Type	Editorial
Article Title	β-cell dedifferentiation in type 2 diabetes: Interplay of metabolic stress, endoplasmic reticulum dysfunction, and forkhead box protein O1 inhibition
Manuscript Source	Invited Manuscript
All Author List	Ashraf Al Madhoun, Fatemah Bahman and Rasheed Ahmad
Funding Agency and Grant Number	Funding Agency Grant Number Kuwait Foundation for the Advancement of Sciences RACB-2021-007
Corresponding Author	Ashraf Al Madhoun, Senior Scientist, Department of Translational Medicine, Dasman Diabetes Institute, Jassim AlBahar Street, Dasman 15400, Kuwait. ashraf.madhoun@dasmaninstitute.org
Key Words	Aldehyde dehydrogenase 1 family member A3; Forkhead box protein O1; Endoplasmic reticulum stress; Dedifferentiation; Pancreatic β-cells; Diabetes
Core Tip	This editorial highlights the emerging role of β-cell dedifferentiation as a central mechanism of β-cell failure in type 2 diabetes, alongside apoptosis. We emphasize recent findings that chronic metabolic stressors, namely glucotoxicity and lipotoxicity, initiate ER stress and suppress forkhead box protein O1 activity, leading to the loss of β-cell identity and function. The reversibility of this process introduces new therapeutic possibilities aimed at preserving or restoring endogenous insulin production.
Citation	Al Madhoun A, Bahman F, Ahmad R. β-cell dedifferentiation in type 2 diabetes: Interplay of metabolic stress, endoplasmic reticulum dysfunction, and forkhead box protein O1 inhibition. World J Diabetes 2025; In press

Received	2025-05-07 14:03
Peer-Review Started	2025-05-09 07:12
To Make the First Decision
Return for Revision	2025-05-15 06:39
Revised	2025-06-02 05:10
Second Decision	2025-07-31 02:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-31 08:19
Articles in Press	2025-07-31 08:19
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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