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Publication Name World Journal of Diabetes
Manuscript ID 109274
Country Kuwait
Category Biochemistry & Molecular Biology
Manuscript Type Editorial
Article Title β-cell dedifferentiation in type 2 diabetes: Interplay of metabolic stress, endoplasmic reticulum dysfunction, and forkhead box protein O1 inhibition
Manuscript Source Invited Manuscript
All Author List Ashraf Al Madhoun, Fatemah Bahman and Rasheed Ahmad
Funding Agency and Grant Number
Funding Agency Grant Number
Kuwait Foundation for the Advancement of Sciences RACB-2021-007
Corresponding Author Ashraf Al Madhoun, Senior Scientist, Department of Translational Medicine, Dasman Diabetes Institute, Jassim AlBahar Street, Dasman 15400, Kuwait. ashraf.madhoun@dasmaninstitute.org
Key Words Diabetes; Pancreatic β-cells; Dedifferentiation; Endoplasmic reticulum stress; Forkhead box protein O1; Aldehyde dehydrogenase 1 family member A3
Core Tip This editorial highlights the emerging role of β-cell dedifferentiation as a central mechanism of β-cell failure in type 2 diabetes, alongside apoptosis. We emphasize recent findings that chronic metabolic stressors, namely glucotoxicity and lipotoxicity, initiate ER stress and suppress forkhead box protein O1 activity, leading to the loss of β-cell identity and function. The reversibility of this process introduces new therapeutic possibilities aimed at preserving or restoring endogenous insulin production.
Citation Al Madhoun A, Bahman F, Ahmad R. β-cell dedifferentiation in type 2 diabetes: Interplay of metabolic stress, endoplasmic reticulum dysfunction, and forkhead box protein O1 inhibition. World J Diabetes 2025; In press
Received
2025-05-07 14:03
Peer-Review Started
2025-05-09 07:12
To Make the First Decision
Return for Revision
2025-05-15 06:39
Revised
2025-06-02 05:10
Second Decision
2025-07-31 02:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief
2025-07-31 08:19
Articles in Press
2025-07-31 08:19
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 1948-9358 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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