Publication Name	World Journal of Stem Cells
Manuscript ID	109284
Country	China

Category	Cell Biology
Manuscript Type	Basic Study
Article Title	Melanoma cell adhesion molecule-positive mesenchymal stromal cells alleviate acute respiratory distress syndrome via nuclear factor kappa-B-mediated paracrine regulation
Manuscript Source	Unsolicited Manuscript
All Author List	Ya-Li Zhang, Ding-Ke Wen, Sheng-Nan Wang, Yi Tan and He-Ran Ma
Funding Agency and Grant Number	Funding Agency Grant Number Science and Technology SMEs Innovation Capacity Improvement Project of Shandong Province 2022TSGC1004 National Key R&D Program of China 2021YFA1101502
Corresponding Author	He-Ran Ma, Manager, PhD, Department of Research and Development, Qilu Cell Therapy Technology Co., Ltd, No. 6 Gangyuan Road, Licheng District, Jinan 250000, Shandong Province, China. maheran@yinfeng.com.cn
Key Words	Mesenchymal stromal cells; Melanoma cell adhesion molecule; Acute respiratory distress syndrome; Nuclear factor kappa B; CD146
Core Tip	Mesenchymal stromal cells (MSCs) are recognized for their immunosuppressive properties and are widely used to control excessive inflammation. This study demonstrated that, compared with CD146- MSCs, CD146+ MSCs exhibit greater secretion of pro-angiogenic factors and enhanced anti-inflammatory and immunomodulatory capacities. CD146+ MSCs repair epithelial cells by activating the nuclear factor kappa B/cyclooxygenase 2 pathway, thereby exerting superior therapeutic efficacy in the treatment of acute respiratory distress syndrome.
Citation	Zhang YL, Wen DK, Wang SN, Tan Y, Ma HR. Melanoma cell adhesion molecule-positive mesenchymal stromal cells alleviate acute respiratory distress syndrome via nuclear factor kappa-B-mediated paracrine regulation. World J Stem Cells 2025; In press

Received	2025-05-08 05:52
Peer-Review Started	2025-05-08 05:52
To Make the First Decision
Return for Revision	2025-06-12 07:07
Revised	2025-06-24 08:26
Second Decision	2025-08-26 08:33
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-08-27 10:03
Articles in Press	2025-08-27 10:03
Publication Fee Transferred	2025-06-25 01:10
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com