Publication Name	World Journal of Clinical Cases
Manuscript ID	109358
Country	China

Category	Nursing
Manuscript Type	Case Report
Article Title	Effective application of an innovative acemannan-enriched glycolipid sphere dressing in diabetic foot ulcer wound healing: A case report and review of literature
Manuscript Source	Unsolicited Manuscript
All Author List	Shu-Ting Mei and Jie-Jing Li
Funding Agency and Grant Number
Corresponding Author	Jie-Jing Li, Associate Professor, PhD, Department of Research, Guangzhou Oriplamacy Technology Co., Ltd., No. 918 Middle Guangzhou Avenue, Guangzhou 510000, Guangdong Province, China. jiejingli@ext.jnu.edu.cn
Key Words	Acemannan; Diabetic foot ulcer; Wound healing; Aloe vera; Glycolipid sphere dressing; Case report
Core Tip	This study reports the successful use of an acemannan-enriched glycolipid sphere dressing derived from aloe vera gel for treating a severe diabetic foot ulcer (DFU). An 80-year-old female with long-standing type 2 diabetes mellitus, presented with a nonhealing DFU (Texas classification: Grade II, stage D). Treatment involved applying the dressing five times daily, later reduced to three times after scab formation, alongside lifestyle management. Complete healing occurred within 5 mo without significant scarring or functional loss, and no recurrence was observed during two years of follow-up. This case highlights the potential of acemannan-enriched dressings for DFU and other refractory wound treatments.
Citation	Mei ST, Li JJ. Effective application of an innovative acemannan-enriched glycolipid sphere dressing in diabetic foot ulcer wound healing: A case report and review of literature. World J Clin Cases 2025; In press

Received	2025-05-09 08:26
Peer-Review Started	2025-05-09 08:27
To Make the First Decision
Return for Revision	2025-06-04 01:47
Revised	2025-06-16 11:59
Second Decision	2025-07-14 02:41
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-15 02:24
Articles in Press	2025-07-15 02:24
Publication Fee Transferred	2025-06-19 02:55
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2307-8960 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com