Publication Name	World Journal of Stem Cells
Manuscript ID	109369
Country	China

Category	Cell Biology
Manuscript Type	Basic Study
Article Title	Synovial mesenchymal stem cell-derived exosomes delivering GRPEL1 activate PINK1-mediated mitophagy to promote cartilage repair in arthritis
Manuscript Source	Unsolicited Manuscript
All Author List	Cheng-Hao Xiang, Li Zou, Zhao-Gang Huang, Guo-Jun Zhang, Hui-Long Zeng, Ze-Xing He and Zhang-Sheng Dai
Funding Agency and Grant Number	Funding Agency Grant Number Scientific Research Project of the Traditional Chinese Medicine Administration of Hubei Provincial Health Commission ZY2025L268
Corresponding Author	Zhang-Sheng Dai, Chief Physician, Department of Orthopedics, The Second Affiliated Hospital of Fujian Medical University, No. 950 Donghai Avenue, Quanzhou 362000, Fujian Province, China. daizhangsheng@126.com
Key Words	Osteoarthritis; Exosomes; Synovial mesenchymal stem cell; Cartilage repair; GrpE-like 1; Phosphatase and tensin homolog-induced putative kinase 1
Core Tip	This study demonstrates that synovial mesenchymal stem cell-derived exosomes engineered to deliver GrpE-like 1 effectively enhance phosphatase and tensin homolog-induced putative kinase 1-mediated mitophagy, promoting cartilage repair in osteoarthritis. By integrating bioinformatics, in vitro chondrocyte assays, and in vivo rat models, the findings reveal a novel mechanism by which GrpE-like 1 activates mitochondrial quality control and reduces oxidative stress. This work introduces a promising exosome-based therapeutic strategy that targets mitochondrial dysfunction, advancing the development of disease-modifying treatments beyond current symptomatic approaches for osteoarthritis.
Citation	Xiang CH, Zou L, Huang ZG, Zhang GJ, Zeng HL, He ZX, Dai ZS. Synovial mesenchymal stem cell-derived exosomes delivering GRPEL1 activate PINK1-mediated mitophagy to promote cartilage repair in arthritis. World J Stem Cells 2025; In press

Received	2025-05-14 03:08
Peer-Review Started	2025-05-14 03:09
To Make the First Decision
Return for Revision	2025-06-10 04:50
Revised	2025-06-24 03:30
Second Decision	2025-09-03 02:54
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-04 10:32
Articles in Press	2025-09-04 10:32
Publication Fee Transferred	2025-07-07 06:26
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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