Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	109379
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Yttrium-90 microsphere therapy for hepatocellular carcinoma: Clinical efficacy, mechanistic insights, and comparative therapeutic perspectives
Manuscript Source	Invited Manuscript
All Author List	Yu-Hang Zhu, Ming-Wei Wang, Yan Jiao, Ya-Hui Liu and Shan-Shan Dong
Funding Agency and Grant Number
Corresponding Author	Ya-Hui Liu, Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The First Hospital of Jilin University, Xinmin Street, Changchun 130021, Jilin Province, China. yahui@jlu.edu.cn
Key Words	Hepatocellular carcinoma; Yttrium-90 microsphere therapy; Radioembolization; Dosimetry; Clinical outcomes; Comparative efficacy
Core Tip	Yttrium-90 (Y-90) microsphere therapy effectively prolongs overall survival and progression-free survival in hepatocellular carcinoma patients, demonstrating excellent tumor response rates and minimal severe adverse events. Advanced dosimetry and integration with systemic therapies further enhance its efficacy. Compared to conventional treatments, Y-90 offers improved local tumor control and better safety, marking it a pivotal component in contemporary multimodal cancer management.
Citation	Zhu YH, Wang MW, Jiao Y, Liu YH, Dong SS. Yttrium-90 microsphere therapy for hepatocellular carcinoma: Clinical efficacy, mechanistic insights, and comparative therapeutic perspectives. World J Gastrointest Oncol 2025; In press

Received	2025-05-09 10:32
Peer-Review Started	2025-05-09 10:32
To Make the First Decision
Return for Revision	2025-05-17 08:22
Revised	2025-05-19 02:12
Second Decision	2025-06-06 02:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-06 06:30
Articles in Press	2025-06-06 06:30
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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