Publication Name	World Journal of Nephrology
Manuscript ID	109400
Country	United States

Category	Urology & Nephrology
Manuscript Type	Case Report
Article Title	Avacopan in the treatment of relapsing polychondritis with myeloperoxidase-antineutrophil cytoplasmic antibody associated vasculitis: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Jack Tang Nguyen and Manish Anand
Funding Agency and Grant Number
Corresponding Author	Jack Tang Nguyen, Doctorate Student, College of Medicine, University of Cincinnati, 3230 Eden Ave, Cincinnati, OH 45220, United States. nguyenjack91801@gmail.com
Key Words	Antineutrophil cytoplasmic antibody; Polychondritis; Vasculitis; Myeloperoxidase-antineutrophil cytoplasmic antibody; Case report
Core Tip	This case report presents a rare overlap of relapsing polychondritis and myeloperoxidase anti-neutrophil cytoplasmic antibody associated vasculitis, complicated by severe acute kidney injury. The patient demonstrated sustained renal improvement following treatment with Avacopan, a complement 5a receptor antagonist, after intolerance to rituximab. This case highlights the potential role of Avacopan in preserving renal function and achieving disease control in complex autoimmune syndromes, especially when conventional immunosuppressive regimens are contraindicated or poorly tolerated.
Citation	Nguyen JT, Anand M. Avacopan in the treatment of relapsing polychondritis with myeloperoxidase-antineutrophil cytoplasmic antibody associated vasculitis: A case report. World J Nephrol 2025; In press

Received	2025-05-12 02:59
Peer-Review Started	2025-05-13 08:46
To Make the First Decision
Return for Revision	2025-05-23 11:27
Revised	2025-05-28 01:07
Second Decision	2025-07-10 02:46
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-10 03:14
Articles in Press	2025-07-10 03:14
Publication Fee Transferred	2025-05-29 18:22
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-6124 (online)
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