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Publication Name World Journal of Nephrology
Manuscript ID 109400
Country United States
Category Urology & Nephrology
Manuscript Type Case Report
Article Title Avacopan in the treatment of relapsing polychondritis with myeloperoxidase-antineutrophil cytoplasmic antibody associated vasculitis: A case report
Manuscript Source Unsolicited Manuscript
All Author List Jack Tang Nguyen and Manish Anand
Funding Agency and Grant Number
Corresponding Author Jack Tang Nguyen, Doctorate Student, College of Medicine, University of Cincinnati, 3230 Eden Ave, Cincinnati, OH 45220, United States. nguyenjack91801@gmail.com
Key Words Antineutrophil cytoplasmic antibody; Polychondritis; Vasculitis; Myeloperoxidase-antineutrophil cytoplasmic antibody; Case report
Core Tip This case report presents a rare overlap of relapsing polychondritis and myeloperoxidase anti-neutrophil cytoplasmic antibody associated vasculitis, complicated by severe acute kidney injury. The patient demonstrated sustained renal improvement following treatment with Avacopan, a complement 5a receptor antagonist, after intolerance to rituximab. This case highlights the potential role of Avacopan in preserving renal function and achieving disease control in complex autoimmune syndromes, especially when conventional immunosuppressive regimens are contraindicated or poorly tolerated.
Citation Nguyen JT, Anand M. Avacopan in the treatment of relapsing polychondritis with myeloperoxidase-antineutrophil cytoplasmic antibody associated vasculitis: A case report. World J Nephrol 2025; In press
Received
2025-05-12 02:59
Peer-Review Started
2025-05-13 08:46
To Make the First Decision
Return for Revision
2025-05-23 11:27
Revised
2025-05-28 01:07
Second Decision
2025-07-10 02:46
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief
2025-07-10 03:14
Articles in Press
2025-07-10 03:14
Publication Fee Transferred
2025-05-29 18:22
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 2220-6124 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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