Publication Name	World Journal of Psychiatry
Manuscript ID	109425
Country	China

Category	Psychiatry
Manuscript Type	Basic Study
Article Title	Brain region and cell specificity of B4GALT6 in depressive-like behavior mice: A pilot study
Manuscript Source	Unsolicited Manuscript
All Author List	Shi-Na Zhang, Di Luan, Bo-Yang Sheng, Bing Xie and Le Xiao
Funding Agency and Grant Number	Funding Agency Grant Number Hunan Provincial Natural Science Foundation of China 2025JJ80473 Hunan Provincial Natural Science Foundation of China 2025JJ80484 the Institute of Hospital Management, National Health Commission of China, Major Project SZ2024HL021
Corresponding Author	Le Xiao, Chief Physician, Rehabilitation Medicine Department, The First Hospital of Changsha, (The Affiliated Changsha Hospital of Xiangya School of Medicine, Central South University), 311 Yingpan Road, Kaifu District, Changsha 410005, Hunan Province, China. teacherfnr@163.com
Key Words	Major depressive disorder; rs372369000; B4GALT6; Potential therapeutic target; Gene expression
Core Tip	Major depressive disorder (MDD) poses a serious threat to human life. The SNP rs372369000 located within the β-1,4-galactosyltransferase 6 (B4GALT6) gene is a risk locus for MDD. However, the pathological mechanism of B4GALT6 in the brain concerning MDD remain unclear. We developed an inflammation-associated depression model and examined the brain distributions and level alterations of B4GALT6-like immunoreactivity. Our findings indicate the expression of B4GALT6-like immunoreactivity increased in the hippocampus, PrL, and the visual cortex V1 region of these mice. This elevation varied across different brain subregions and cell types. B4GALT6 may emerge as a potential therapeutic target for MDD.
Citation	Zhang SN, Luan D, Sheng BY, Xie B, Le X. Brain region and cell specificity of B4GALT6 in depressive-like behavior mice: A pilot study. World J Psychiatry 2025; In press

Received	2025-05-12 11:26
Peer-Review Started	2025-05-21 09:11
To Make the First Decision
Return for Revision	2025-06-18 02:01
Revised	2025-06-27 14:10
Second Decision	2025-08-01 02:46
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-08-08 06:18
Articles in Press	2025-08-08 06:18
Publication Fee Transferred	2025-07-02 14:05
Edit the Manuscript by Language Editor	2025-08-12 21:20
Typeset the Manuscript

ISSN	2220-3206 (online)
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