Publication Name	World Journal of Hepatology
Manuscript ID	109429
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Interleukin-36 subfamily cytokines in liver diseases
Manuscript Source	Unsolicited Manuscript
All Author List	Zhe-Kun Xiong, Si-Min Gu and Yi-Yuan Zheng
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82104549
Corresponding Author	Yi-Yuan Zheng, Department of Gastroenterology, Shanghai Municipal Hospital of Traditional Chinese Medicine, No. 274 Zhijiang Middle Road, Shanghai 200071, China. iceroser@126.com
Key Words	Interleukin-36; Inflammation; Macrophages; T cells; Liver cirrhosis; Metabolic dysfunction-associated liver disease; Gut microbiota
Core Tip	This letter discusses the important role of the interleukin-36 (IL-36) subfamily in the pathogenesis of liver diseases, particularly in modulating immune responses and promoting inflammation. Although considerable knowledge gaps remain regarding the precise mechanisms through which IL-36 cytokines contribute to liver damage, emerging evidence suggests that the targeting of IL-36 signaling may present novel therapeutic avenues for the management of chronic liver diseases. Further research is essential to investigate the potential of IL-36 as both a biomarker and a therapeutic target within clinical contexts.
Citation	Xiong ZK, Gu SM, Zheng YY. Interleukin-36 subfamily cytokines in liver diseases. World J Hepatol 2025; In press

Received	2025-05-12 03:37
Peer-Review Started	2025-05-12 08:49
To Make the First Decision
Return for Revision	2025-05-29 08:53
Revised	2025-06-06 08:05
Second Decision	2025-07-31 02:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-31 08:31
Articles in Press	2025-07-31 08:31
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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