Publication Name	World Journal of Diabetes
Manuscript ID	109597
Country	China

Category	Dermatology
Manuscript Type	Case Report
Article Title	Diabetic foot ulcer with overlap syndrome: A case report and review of literature
Manuscript Source	Unsolicited Manuscript
All Author List	Shi-Yi Sun, Da-Wei Chen, Jing Wu, Yan Li and Xing-Wu Ran
Funding Agency and Grant Number	Funding Agency Grant Number 1.3.5 Project for Excellence, West China Hospital of Sichuan University No. ZYGD24005 1.3.5 Project of Center for High Altitude Medicine, West China Hospital, Sichuan University No. GYYX24002 Sichuan Science and Technology Program No. 2024YFFK0290 Health Commission of Sichuan Province No. 23LCYJ042 Science and Technology Department of Sichuan Province No. 2025ZNSFSC1621
Corresponding Author	Xing-Wu Ran, Chief Physician, MD, Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, No. 37 Guoxue Lane, Chengdu 610041, Sichuan Province, China. ranxingwu@163.com
Key Words	Diabetic foot ulcer; Overlap syndrome; Anti-synthetase syndrome; Systemic scleroderma; Case report
Core Tip	Diabetic foot ulcers (DFUs), although common in diabetes, rarely coexist with connective tissue diseases, particularly overlap syndromes. We describe a unique case involving DFUs with overlap syndrome [systemic sclerosis (SSc) and anti-synthetase syndrome (ASS)]. Literature analysis revealed three key patterns in SSc-related foot ulcers: Low incidence, predominant toe involvement, and rare diabetes comorbidity. No ASS-related foot ulcer cases have been reported. The prognosis of SSc-related foot ulcers is generally favorable, with standard DFU therapies (notably autologous platelet-rich gel) showing efficacy. Bosentan and calcium channel blockers may have therapeutic and preventive effects on SSc-related foot ulcers.
Citation	Sun SY, Chen DW, Wu J, Li Y, Ran XW. Diabetic foot ulcer with overlap syndrome: A case report and review of literature. World J Diabetes 2025; In press

Received	2025-05-19 02:18
Peer-Review Started	2025-05-20 00:10
To Make the First Decision
Return for Revision	2025-06-11 03:48
Revised	2025-06-20 01:41
Second Decision	2025-07-31 02:41
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-08-13 08:55
Articles in Press	2025-08-13 08:55
Publication Fee Transferred	2025-06-24 04:18
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ISSN	1948-9358 (online)
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