Publication Name	World Journal of Cardiology
Manuscript ID	109627
Country	United States

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Systematic Reviews
Article Title	Interplay of menopause, coronary artery calcium score and cardiovascular disease risk
Manuscript Source	Invited Manuscript
All Author List	Tanisha Mishra, Diksha Sanjana Pasnoor, Murtaza Gandhi, Nida Mohamed, Shaylika Chauhan, Kokou Adompreh-Fia, Kesha Mayank Doshi, Rupak Desai and Prerana Sevella
Funding Agency and Grant Number
Corresponding Author	Shaylika Chauhan, FACP, MD, Department of Internal Medicine, Geisinger Health System, 1000 E Mountain Blvd, Wikes-Barre, PA 18711, United States. drshaylikachauhan@gmail.com
Key Words	Coronary artery calcium score; Menopause; Cardiovascular disease; Coronary artery disease; Coronary calcification; Postmenopausal
Core Tip	Our review critically examines an understudied interplay- menopause, coronary artery calcium score (CACS), and cardiovascular disease (CVD), highlighting estrogen withdrawal’s role in accelerating subclinical atherosclerosis. It analyzes current evidence on the role of metabolic dysregulation, bone mineral density, lipid shifts, insulin resistance, and triglyceride-glucose index as mediators of increased CACS. Given the rising global burden of CVD in aging female populations and the growing use of CACS, this review is especially timely in guiding risk assessment during the menopausal transition. Future research should focus on integrating CACS to traditional risk assessment tools for early CVD detection and prevention.
Citation	Mishra T, Pasnoor DS, Gandhi M, Mohamed N, Chauhan S, Adompreh-Fia K, Doshi KM, Sevella P, Desai R. Interplay of menopause, coronary artery calcium score and cardiovascular disease risk. World J Cardiol 2025; In press

Received	2025-05-18 04:35
Peer-Review Started	2025-05-18 04:36
To Make the First Decision
Return for Revision	2025-05-22 11:39
Revised	2025-06-14 17:14
Second Decision	2025-10-24 02:43
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-10-25 01:25
Articles in Press	2025-10-25 01:25
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Typeset the Manuscript

ISSN	1949-8462 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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