Publication Name	World Journal of Stem Cells
Manuscript ID	109662
Country	China

Category	Dentistry, Oral Surgery & Medicine
Manuscript Type	Minireviews
Article Title	Post-translational modifications in osteogenic differentiation of oral-derived stem cells: Mechanisms and clinical implications
Manuscript Source	Invited Manuscript
All Author List	Zhuo-Jin Shi and Wei Liu
Funding Agency and Grant Number
Corresponding Author	Wei Liu, Associate Chief Physician, DDS, Department of Oral Medicine, The Second Affiliated Hospital Zhejiang University School of Medicine, No. 88 Jiefang Road, Hangzhou 310009, Zhejiang Province, China. liuwei1982@zju.edu.cn
Key Words	Oral-derived stem cells; Post-translational modifications; Osteogenic differentiation; Bone regeneration; Signaling pathways; Clinical translation
Core Tip	This review clarifies how post-translational modifications (PTMs), including phosphorylation, acetylation, methylation, and lactylation, dynamically modulate the osteogenic differentiation of oral-derived stem cells (ODSCs) under inflammatory or hypoxic conditions. We highlight PTMs as essential molecular switches integrating extracellular signals with transcriptional and epigenetic mechanisms to facilitate bone regeneration. Emerging therapeutic strategies - including histone deacetylase inhibitors, extracellular vesicle-based delivery, and metabolic-epigenetic crosstalk modulation - are proposed to improve ODSCs efficacy in osteoporosis and periodontitis. This review clarifies the PTMs “regulatory code” in ODSCs, connecting mechanistic insights to clinical translation while addressing unresolved challenges in precision regenerative medicine.
Citation	Shi ZJ, Liu W. Post-translational modifications in osteogenic differentiation of oral-derived stem cells: Mechanisms and clinical implications. World J Stem Cells 2025; In press

Received	2025-05-18 04:49
Peer-Review Started	2025-05-18 04:49
To Make the First Decision
Return for Revision	2025-06-11 03:42
Revised	2025-06-22 00:22
Second Decision	2025-08-10 13:58
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-08-13 09:16
Articles in Press	2025-08-13 09:16
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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