Publication Name	World Journal of Gastroenterology
Manuscript ID	109687
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Preoperative risk stratification of early recurrence in resected pancreatic ductal adenocarcinoma: Novel equilibrium-phase-computed tomography biomarker of extracellular volume
Manuscript Source	Unsolicited Manuscript
All Author List	Zhi-Wei Zhang, Hao-Tian Liu, Zhuo-Hang Zhou, Hong-Fan Liao, Lan-Ling Zhang, Yong-Mei Li and Hong-Wei Liang
Funding Agency and Grant Number	Funding Agency Grant Number Chongqing Medical Scientific Research Project (Joint Project of Chongqing Health Commission and Science and Technology Bureau) No. 2025MSXM043
Corresponding Author	Hong-Wei Liang, PhD, Department of Radiology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuzhong District, Chongqing 400016, China. lianghongwei2021@163.com
Key Words	Pancreatic ductal adenocarcinoma; Equilibrium-phase computed tomography; Extracellular volume; Early recurrence; Carbohydrate antigen 19-9
Core Tip	This study demonstrates that preoperative computed tomography (CT)-derived extracellular volume (CT-ECV) is an independent predictor of early recurrence in pancreatic ductal adenocarcinoma after R0 resection. Elevated CT-ECV, high carbohydrate antigen 19-9 (CA19-9), and poor tumor grade were significantly associated with shorter recurrence-free survival. Combining CT-ECV and CA19-9 improved predictive accuracy over tumor grade alone, offering a non-invasive tool for preoperative risk stratification and personalized postoperative management.
Citation	Zhang ZW, Liu HT, Zhou ZH, Liao HF, Zhang LL, Li YM, Liang HW. Preoperative risk stratification of early recurrence in resected pancreatic ductal adenocarcinoma: Novel equilibrium-phase-computed tomography biomarker of extracellular volume. World J Gastroenterol 2025; In press

Received	2025-05-26 09:28
Peer-Review Started	2025-05-26 09:28
To Make the First Decision
Return for Revision	2025-05-30 18:17
Revised	2025-06-21 03:42
Second Decision	2025-08-15 02:56
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-08-15 10:52
Articles in Press	2025-08-15 10:52
Publication Fee Transferred	2025-06-24 14:49
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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