Publication Name	World Journal of Clinical Cases
Manuscript ID	109701
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Revitalizing liver health: Human placental extract shows promise in chronic liver disease management
Manuscript Source	Invited Manuscript
All Author List	Yang Liu, Yan Wang and Xiao-Jun Yang
Funding Agency and Grant Number	Funding Agency Grant Number PhD Supervisor Training Program 22GSSYA-3 Gansu Provincial Health Industry Research Project GSWSKY2020-45 Gansu Natural Science Foundation 20JR10RA378
Corresponding Author	Xiao-Jun Yang, MD, PhD, Professor, Department of General Surgery, Gansu Provincial People’s Hospital, No. 199 Donggang West Road, Chengguan District, Lanzhou 730000, Gansu Province, China. yangxjmd@aliyun.com
Key Words	Human placental extract; Chronic liver disease; Liver fibrosis; Regenerative medicine; Antioxidant; Clinical translation
Core Tip	An innovative intervention involving intravenous injection of human placental extract was introduced in a recent case report from Danann Medical Clinic, which aimed to improve the liver functions of chronic liver disease patients. However, the study was restricted by the issues, including a small sample size, absence of a control group, and insufficient long-term safety data, and the mechanistic underpinnings and generalizability of therapeutic efficacy required further validation.
Citation	Liu Y, Wang Y, Yang XJ. Revitalizing liver health: Human placental extract shows promise in chronic liver disease management. World J Clin Cases 2025; In press

Received	2025-05-19 14:57
Peer-Review Started	2025-05-19 14:57
To Make the First Decision
Return for Revision	2025-06-06 03:41
Revised	2025-06-18 18:19
Second Decision	2025-08-14 03:14
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-08-15 01:46
Articles in Press	2025-08-15 01:46
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ISSN	2307-8960 (online)
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