Publication Name	World Journal of Clinical Oncology
Manuscript ID	109730
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Overview of Yttrium-90 radioembolization for advanced hepatocellular carcinoma: Current status and future perspectives
Manuscript Source	Invited Manuscript
All Author List	Zong-Yang Li, Cheng Xie and Hong-Qiao Cai
Funding Agency and Grant Number
Corresponding Author	Hong-Qiao Cai, MD, PhD, Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The First Hospital of Jilin University, No. 1 Xinmin Street, Changchun 130021, Jilin Province, China. hongqiaocai@jlu.edu.cn
Key Words	Hepatocellular carcinoma; Radioembolization; Yttrium-90; Portal vein tumor thrombosis; Selective internal radiation therapy
Core Tip	Radioembolization with yttrium-90 microspheres represents a pivotal locoregional treatment option for patients with advanced hepatocellular carcinoma (HCC), especially those with portal vein tumor thrombosis or limited tolerance to systemic therapies. Landmark trials confirm its favorable safety profile and potential for tumor downstaging. Emerging strategies such as personalized dosimetry and combination with immunotherapy are poised to enhance efficacy. Radioembolization continues to evolve as a core component of multimodal therapy in advanced HCC management.
Citation	Li ZY, Xie C, Cai HQ. Overview of Yttrium-90 radioembolization for advanced hepatocellular carcinoma: Current status and future perspectives. World J Clin Oncol 2025; In press

Received	2025-05-20 07:02
Peer-Review Started	2025-05-20 07:02
To Make the First Decision
Return for Revision	2025-05-24 02:50
Revised	2025-05-27 02:55
Second Decision	2025-07-10 02:46
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-10 03:24
Articles in Press	2025-07-10 03:24
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
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