Publication Name	World Journal of Hepatology
Manuscript ID	109745
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Current clinical research status and future treatment directions for liver cirrhosis combined with portal vein thrombosis
Manuscript Source	Invited Manuscript
All Author List	Wen-Long He, Shuai Yan, Jia-Jie Lu, Lin Chen and Jin-Zhu Wu
Funding Agency and Grant Number
Corresponding Author	Jin-Zhu Wu, Chief Physician, MD, Professor, Department of Hepatobiliary Surgery, Nantong Third People’s Hospital, No. 19 Qixiu Road, Chongchuan District, Nantong 226300, Jiangsu Province, China. wjz1258@163.com
Key Words	Liver cirrhosis; Portal vein thrombosis; Anticoagulation; Edoxaban; Direct-acting oral anticoagulants; Portal hypertension; Thrombolysis
Core Tip	Portal vein thrombosis represents a significant complication of liver cirrhosis and contributes to the exacerbation of portal hypertension and results in severe clinical outcomes including oesophageal variceal bleeding and refractory ascites. This review presents a comprehensive overview of the aetiology, diagnosis, clinical manifestations, and treatment options for portal vein thrombosis in cirrhotic patients. Furthermore, this highlights the emerging role of direct oral anticoagulants, such as edoxaban, which offer promising therapeutic potential because of their efficacy, safety, and convenience. Future research should address individualized treatment strategies to optimize the balance between anticoagulation benefits and bleeding risks, which improves patient prognosis.
Citation	He WL, Yan S, Lu JJ, Chen L, Wu JZ. Current clinical research status and future treatment directions for liver cirrhosis combined with portal vein thrombosis. World J Hepatol 2025; In press

Received	2025-05-20 07:19
Peer-Review Started	2025-05-21 00:08
To Make the First Decision
Return for Revision	2025-05-24 02:51
Revised	2025-06-04 16:02
Second Decision	2025-09-22 02:45
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-22 09:34
Articles in Press	2025-09-22 09:34
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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