Publication Name	World Journal of Hepatology
Manuscript ID	109770
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Clinical characteristics and genetic causes of unexplained pediatric liver disease
Manuscript Source	Unsolicited Manuscript
All Author List	Yuan Chen, Zhi-Yi Wang, Bao-Qi Chen, Yu-Juan Qi, Hai-Yan Liu, Wen-Xin Shi, Lu Guo, Zhi Liu and Li-Feng Sun
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82400641 Natural Science Foundation of Shandong Province ZR2022QH076 and ZR2021MH381
Corresponding Author	Li-Feng Sun, Associate Chief Physician, Pediatric Gastroenterology Fellow, PhD, Department of Pediatrics, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No. 324 Jing Wu Road, Jinan 250021, Shandong Province, China. lifengsun2008@163.com
Key Words	Whole-exome sequencing; Liver disease; Pediatric; Wilson's disease; Alagille syndrome
Core Tip	In recent years, the number of pediatric patients with unexplained liver disease has been increasing. Whole-exome sequencing (WES) technology has played a significant role in the diagnosis; however, related studies remain limited. We found that WES significantly increased the diagnosis rate of liver diseases of unknown cause in children, guided personalized treatment, and improved prognosis. The mutation spectra of genes such as ATP7B and JAG1 provide important references for the molecular diagnosis of inherited liver diseases in Chinese children. In the future, functional studies and multi-omics integration will be required to elucidate the pathogenic mechanisms of novel variants and to advance the application of precision medicine in the field of pediatric hepatology.
Citation	Chen Y, Wang ZY, Chen BQ, Qi YJ, Liu HY, Shi WX, Guo L, Liu Z, Sun LF. Clinical characteristics and genetic causes of unexplained pediatric liver disease. World J Hepatol 2025; In press

Received	2025-06-06 16:47
Peer-Review Started	2025-06-06 16:48
To Make the First Decision
Return for Revision	2025-06-13 07:03
Revised	2025-06-26 16:24
Second Decision	2025-09-29 02:34
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-29 04:09
Articles in Press	2025-09-29 04:09
Publication Fee Transferred	2025-06-28 13:36
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Typeset the Manuscript

ISSN	1948-5182 (online)
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