Publication Name	World Journal of Diabetes
Manuscript ID	109815
Country	China

Category	Cell Biology
Manuscript Type	Basic Study
Article Title	Exosomal transfer of miR-375-3p from pancreatic β cells to hepatocytes impairs hepatic glycogenesis via Rbpj repression
Manuscript Source	Unsolicited Manuscript
All Author List	Fang-Zhi Xu, Lin Dou, Xi Wu, Chen-Xi Xia, Dong-Ni Yu, Yong Man, Tao Shen and Xiu-Qing Huang
Funding Agency and Grant Number	Funding Agency Grant Number National High Level Hospital Clinical Research Funding BJ-2024-219, BJ-2025-125 and BJ-2023-236 Beijing Natural Science Foundation 7252124 National Key R&D Program of China 2021YFE0114200 National Natural Science Foundation of China 82370584, 82470395 and 81600618
Corresponding Author	Xiu-Qing Huang, PhD, The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital, No. 1 Dahua Road, Dongdan, Dongcheng District, Beijing 100730, China. huang_xq118@126.com
Key Words	Exosomes; Glycogenesis; Pancreatic β cell; MiR-375-3p; Hepatocytes
Core Tip	Glucotoxic pancreatic β cells impair glycogenesis of hepatocytes, with exosomes serving as novel mediators. Glucotoxicity increased the expression of miR-375-3p in pancreatic cells but had no effect on hepatocytes. Exosomal transfer of miR-375-3p from pancreatic β cells to hepatocytes enables it to directly target and inhibit the recombination signal binding protein for the immunoglobulin kappa J region (Rbpj). This suppression of Rbpj subsequently impairs the AKT/GSK-3 signaling pathway, thereby reducing hepatic glycogen content.
Citation	Xu FZ, Dou L, Wu X, Xia CX, Yu DN, Man Y, Shen T, Huang XQ. Exosomal transfer of miR-375-3p from pancreatic β cells to hepatocytes impairs hepatic glycogenesis via Rbpj repression. World J Diabetes 2025; In press

Received	2025-05-29 06:08
Peer-Review Started	2025-06-06 09:03
To Make the First Decision
Return for Revision	2025-06-22 10:36
Revised	2025-07-18 11:33
Second Decision	2025-08-26 00:10
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-05 07:15
Articles in Press	2025-09-05 07:15
Publication Fee Transferred	2025-07-19 02:09
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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