| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
MicroRNA-126-3p as a predictive biomarker for patients with primary biliary cholangitis refractory to ursodeoxycholic acid
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Shi-Da Pan, Chu-Yue Xiong, Ying-Juan Shen, Jia-He Tian, Yi-Lin Wang, Jia-Ning Wang, Si-Yu Wang, Feng-Yi Li, Li-Feng Wang, Qin Qiu, Luo Yang, Xiao-Meng Liu, Jun-Qing Luan, Zheng-Sheng Zou, Fu-Sheng Wang and Fan-Ping Meng |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Key Research and Development Program of China |
2019YFC0840704 |
| Beijing Municipal Science and Technology Program |
Z201100005520047 |
|
| Corresponding Author |
Fan-Ping Meng, Associate Professor, Chief Physician, PhD, Postdoc, Senior Department of Infectious Diseases, The Fifth Medical Center of PLA General Hospital, No. 100 West Fourth Ring Middle Road, Fengtai District, Beijing 100039, China. drmengfanping@126.com |
| Key Words |
Primary biliary cholangitis; MicroRNA; Ursodeoxycholic acid; Efficacy; Early prediction |
| Core Tip |
Patients with primary biliary cholangitis exhibit variable responses to ursodeoxycholic acid (UDCA) therapy, and reliable predictive biomarkers before therapy remain elusive. This study identified 49 differentially expressed microRNAs in patients with different response and explore their potential as predictive biomarkers. MiR-126-3p maintained low expression in the drug-resistant group while showing elevated levels in the sensitive group after therapy. Its expression was significantly positively correlated with UDCA efficacy and negatively associated with total bilirubin and immunoglobulin G levels. The receiver operating characteristic curve analysis demonstrated an area under the curve of 0.891 with a sensitivity of 82.4% and specificity of 84.6%, demonstrating high predictive potential value in patient’s refractory to UDCA. |
| Citation |
<p>Pan SD, Xiong CY, Shen YJ, Tian JH, Wang YL, Wang JN, Wang SY, Li FY, Wang LF, Qiu Q, Yang L, Liu XM, Luan JQ, Zou ZS, Wang FS, Meng FP. MicroRNA-126-3p as a predictive biomarker for patients with primary biliary cholangitis refractory to ursodeoxycholic acid. <i>World J Gastroenterol</i> 2025; 31(31): 109828</p> |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
