Publication Name	World Journal of Diabetes
Manuscript ID	109919
Country	China

Category	Urology & Nephrology
Manuscript Type	Retrospective Study
Article Title	Correlation of gut microbiota metabolite trimethylamine N-oxide with inflammatory levels and osteoporosis in patients with diabetic nephropathy
Manuscript Source	Unsolicited Manuscript
All Author List	Zhang-Lei Pan, Ming-Qiang Li, Jing Zhang, Ling-Yu Xue and Yan-Ping Shi
Funding Agency and Grant Number
Corresponding Author	Yan-Ping Shi, Department of Nephrology, The Second Affiliated Hospital of Shandong First Medical University, Tai’an 271000, Shandong Province, China. shiyanping1823@126.com
Key Words	Diabetic nephropathy; Gut microbiota; Trimethylamine N-oxide; Inflammatory cytokines; Osteoporosis
Core Tip	In recent years, with in-depth research on the gut microbiota and the emergence of concepts such as the "gut-kidney axis" and the "intestinal-bone axis", the key role of the gut microbiota and its metabolites in metabolic disorders, inflammatory responses, and target organ damage has been increasingly recognized. Trimethylamine N-oxide (TMAO) is the main metabolite produced by the gut microbiota from dietary nutrients such as phosphatidylcholine and choline, and has attracted attention due to its participation in the pathogenesis of diabetic nephropathy (DN). In this study, we aim to explore the correlation between TMAO levels and the levels of inflammatory markers and osteoporosis (OP) in patients with DN, providing a theoretical and practical basis for the early identification of high-risk patients and timely clinical intervention. The research results confirm that elevated TMAO levels may mediate the inflammatory response and bone metabolism disorder in patients with DN, thereby promoting the progression of systemic inflammation and OP.
Citation	Pan ZL, Li MQ, Zhang J, Xue LY, Shi YP. Correlation of gut microbiota metabolite trimethylamine N-oxide with inflammatory levels and osteoporosis in patients with diabetic nephropathy. World J Diabetes 2025; In press

Received	2025-06-17 09:37
Peer-Review Started	2025-06-23 00:32
To Make the First Decision
Return for Revision	2025-07-22 08:23
Revised	2025-07-31 04:30
Second Decision	2025-09-22 02:47
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-29 06:14
Articles in Press	2025-09-29 06:14
Publication Fee Transferred	2025-08-01 12:03
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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