Publication Name	World Journal of Stem Cells
Manuscript ID	109942
Country	China

Category	Otorhinolaryngology
Manuscript Type	Prospective Study
Article Title	Long-term follow-up of autologous nasal epithelial stem cell transplantation for congenital olfactory disorders in children
Manuscript Source	Unsolicited Manuscript
All Author List	Xia Ni, Jie Shi, Jian Ning and Xiao-Ling Tian
Funding Agency and Grant Number	Funding Agency Grant Number Hangzhou Medical and Health Technology Project B20210443
Corresponding Author	Xiao-Ling Tian, Department of Otolaryngology, Hangzhou Linping District Integrated Traditional Chinese and Western Medicine Hospital, No. 15 Baojian Road, Linping District, Hangzhou 311100, Zhejiang Province, China. xiang19257489868@163.com
Key Words	Congenital anosmia; Stem cell therapy; Olfactory dysfunction; Pediatric otolaryngology; Regenerative medicine
Core Tip	This prospective study evaluated the long-term outcomes of autologous nasal epithelial stem cell transplantation in children with congenital olfactory disorders. Fifty pediatric patients were followed for 3 years, demonstrating significant improvements in olfactory function, electro-olfactogram readings, and quality of life scores. The treatment was well-tolerated, with only minor, self-limiting complications reported. Age at intervention and baseline residual function were positively associated with better outcomes. These findings offer promising evidence for a novel regenerative approach to pediatric anosmia, addressing a critical gap in current treatment options and paving the way for broader clinical application.
Citation	Ni X, Shi J, Ning J, Tian XL. Long-term follow-up of autologous nasal epithelial stem cell transplantation for congenital olfactory disorders in children. World J Stem Cells 2025; In press

Received	2025-06-27 10:01
Peer-Review Started	2025-06-27 10:01
To Make the First Decision
Return for Revision	2025-07-21 08:20
Revised	2025-07-28 10:01
Second Decision	2025-09-15 00:26
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-22 07:07
Articles in Press	2025-09-22 07:07
Publication Fee Transferred	2025-07-30 09:54
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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