Publication Name	World Journal of Gastroenterology
Manuscript ID	109987
Country	Spain

Category	Gastroenterology & Hepatology
Manuscript Type	Systematic Reviews
Article Title	Beyond corticosteroids: A systematic review of novel therapeutic strategies in severe alcoholic hepatitis and 90-day survival
Manuscript Source	Invited Manuscript
All Author List	Marta Quiñones-Calvo, Rubén Alvarado-Jara, Paula García-Renedo, Elena Stallings, Eulalia Grifol-Clar and Conrado M Fernández-Rodríguez
Funding Agency and Grant Number	Funding Agency Grant Number Hepatology Training Grant from the Spanish Association for The Study of Liver (AEEH-Asociación Española para el Estudio del Hígado) in 2023 G28551570
Corresponding Author	Marta Quiñones-Calvo, MD, Department of Gastroenterology, Hospital Universitario Fundación Alcorcón, Avenida Budapest 1, Alcorcón 28922, Madrid, Spain. m.quinones.2024@alumnos.urjc.es
Key Words	Alcoholic liver disease; Severe alcoholic hepatitis; Corticosteroids; Fecal microbiota transplantation; Granulocyte colony-stimulating factor
Core Tip	Severe alcoholic hepatitis (SAH) is associated with high mortality, yet effective mid-term treatments remain limited. This systematic review exclusively examines survival or mortality at 90-day, synthesizing evidence from eight recent studies. While corticosteroids remain the mainstay of current therapy, their survival benefit appears confined to the first 28 days. In contrast, interventions such as Fecal Microbiota Transplantation and granulocyte colony-stimulating factor have emerged as promising approaches for improving 90-day survival, though further validation is needed. This review highlights the urgent need for innovative therapies and high-quality trials to address mid-term survival in SAH, a critical but underexplored therapeutic window.
Citation	Quiñones-Calvo M, Alvarado-Jara R, García-Renedo P, Stallings E, Grifol-Clar E, Fernández-Rodríguez CM. Beyond corticosteroids: A systematic review of novel therapeutic strategies in severe alcoholic hepatitis and 90-day survival. World J Gastroenterol 2025; In press

Received	2025-05-28 09:29
Peer-Review Started	2025-05-28 09:29
To Make the First Decision
Return for Revision	2025-06-11 07:38
Revised	2025-06-20 19:02
Second Decision	2025-08-11 02:49
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-08-13 09:49
Articles in Press	2025-08-13 09:49
Publication Fee Transferred
Edit the Manuscript by Language Editor	2025-08-19 01:22
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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