Publication Name	World Journal of Clinical Oncology
Manuscript ID	110031
Country	China

Category	Womens Studies
Manuscript Type	Observational Study
Article Title	Fertility anxiety partially mediates depression and recurrence fear in reproductive-age cervical cancer patients: A cross-sectional study
Manuscript Source	Unsolicited Manuscript
All Author List	Xin-Ying He, Ying Huang, Cheng-Ping Qiao, Jiao Ma, Xue Han, Xue-Mei Fan and Qin Chen
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation Youth Project 72204123 China Social Welfare Foundation- Nurse Care Fund HLCXKT-20230130
Corresponding Author	Qin Chen, Chief Nurse, Department of Gynecological Oncology, Women's Hospital of Nanjing Medical University , Nanjing Women and Children's Healthcare Hospital, No. 123 Tianfei Lane, Mochou Road, Qinhuai District, Nanjing 210004, Jiangsu Province, China. qin@njmu.edu.cn
Key Words	Uterine cervical neoplasms; Depression; Fear; Fertility preservation; Mediation analysis; Reproductive age
Core Tip	This study establishes reproductive concerns as a significant partial mediator (accounting for 28.1% of the total effect, β-indirect = 0.152, P < 0.001) between depression and fear of recurrence in 208 childbearing-age cervical cancer patients, using validated scales (Patient Health Questionnaire-9, Reproductive Concerns After Cancer Scale, Fear of Cancer Recurrence Questionnaire) in a cross-sectional design. Strong correlations were observed (reproductive concerns with depression: r = 0.477; with fear of recurrence: r = 0.426), highlighting that depression amplifies fear of recurrence both directly (β-direct = 0.389) and indirectly via fertility-related distress. Given cervical cancer's direct impact on reproductive function and cultural childbearing expectations in populations like China, targeted oncofertility counseling and psychosocial interventions addressing reproductive concerns may concurrently alleviate depressive symptoms and recurrence fears, offering a dual-benefit strategy for survivorship care.
Citation	He XY, Huang Y, Qiao CP, Ma J, Han X, Fan XM, Chen Q. Fertility anxiety partially mediates depression and recurrence fear in reproductive-age cervical cancer patients: A cross-sectional study. World J Clin Oncol 2025; In press

Received	2025-05-28 07:39
Peer-Review Started	2025-05-28 07:39
To Make the First Decision
Return for Revision	2025-06-07 05:57
Revised	2025-06-18 05:53
Second Decision	2025-07-30 02:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-31 08:55
Articles in Press	2025-07-31 08:55
Publication Fee Transferred	2025-06-19 01:30
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com