Publication Name	World Journal of Hepatology
Manuscript ID	110054
Country	Mexico

Category	Biochemistry & Molecular Biology
Manuscript Type	Minireviews
Article Title	Mitochondrial transplantation and platelet rich plasma for the treatment of non-alcoholic fatty liver disease
Manuscript Source	Invited Manuscript
All Author List	Manuel Alejandro Vargas-Vargas, Marcela González-Montoya, Olin Torres-Isidro, Omar Ortiz-Avila, Elizabeth Calderón-Cortés and Christian Cortés-Rojo
Funding Agency and Grant Number	Funding Agency Grant Number Programa Proyectos de Investigación financiados 2025, Coordinación de Investigación Científica, Universidad Michoacana de San Nicolás de Hidalgo, México Secretaría de Ciencia, Humanidades, Tecnología e Innovación, (SECIHTI), México Awarded Postdoctoral Fellowships 472544 Secretaría de Ciencia, Humanidades, Tecnología e Innovación, (SECIHTI), México Awarded Postdoctoral Fellowships 589763
Corresponding Author	Christian Cortés-Rojo, PhD, Professor, Instituto de Investigaciones Químico - Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Edificio B-3, Ciudad Universitaria, Avenida Fco J Mujica, Morelia 58030, Michoacán, Mexico. christian.cortes@umich.mx
Key Words	Non-alcoholic fatty liver disease; Steatohepatitis; Inflammation; Cirrhosis; Oxidative stress; Electron transport chain; Tissue regeneration; Hepatocyte; Steatosis; Mitochondria
Core Tip	Liver diseases driven by mitochondrial dysfunction and oxidative stress have not yet been effectively treated, creating a need for novel therapeutic solutions. Mitochondrial transplantation restores energy metabolism, while platelet rich plasma (PRP) therapy reduces fibrosis via growth factors. This is the first review to propose the combination of mitochondrial transplantation and PRP as a novel therapeutic strategy for non-alcoholic fatty liver disease. The strategy addresses mitochondrial dysfunction, oxidative stress, and fibrosis while promoting liver regeneration, offering a promising alternative where pharmacological treatments are limited.
Citation	Vargas-Vargas MA, González-Montoya M, Torres-Isidro O, Ortiz-Avila O, Calderón-Cortés E, Cortés-Rojo C. Mitochondrial transplantation and platelet rich plasma for the treatment of non-alcoholic fatty liver disease. World J Hepatol 2025; In press

Received	2025-05-28 13:08
Peer-Review Started	2025-06-06 09:02
To Make the First Decision
Return for Revision	2025-06-12 07:54
Revised	2025-06-26 00:59
Second Decision	2025-09-22 02:45
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-22 09:19
Articles in Press	2025-09-22 09:19
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ISSN	1948-5182 (online)
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