Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	110110
Country	Oman

Category	Virology
Manuscript Type	Editorial
Article Title	Missing link: Viral RNA signatures in circulating exosomes as early diagnostic biomarkers for gastrointestinal cancers
Manuscript Source	Invited Manuscript
All Author List	Mahmoud Darweesh and Saeed Mohammadi
Funding Agency and Grant Number	Funding Agency Grant Number Oman Ministry of Higher Education, Research, and Innovation No. BFP/RGP/HSS/24/015
Corresponding Author	Saeed Mohammadi, Assistant Professor, PhD, Natural and Medical Sciences Research Center, University of Nizwa, Birkat Al Mouz University of Nizwa Campus, Nizwa 616, Ad Dakhiliyah, Oman. s.mohammadi@unizwa.edu.om
Key Words	Noncoding RNA; Biomarkers; Hepatitis C virus; Hepatitis B virus; Epstein-Barr virus; Early detection; Gastrointestinal cancer; Liquid biopsy; Viral RNA; Exosomes
Core Tip	Early and accurate diagnostic markers are essential for managing gastrointestinal (GI) cancers, as their prognosis is linked to the stage of detection. This editorial emphasizes the potential of virus-enriched exosomes as a novel, non-invasive diagnostic tool for early detection and monitoring of GI cancers, particularly those associated with oncogenic viruses like Epstein-Barr virus and hepatitis B virus. The viral RNA signatures within these circulating exosomes serve as a crucial missing link, providing specific, and non-invasive biomarkers that can not only aid in distinguishing malignant from benign conditions but also offer insights into tumor progression and potential therapeutic targets.
Citation	Darweesh M, Mohammadi S. Missing link: Viral RNA signatures in circulating exosomes as early diagnostic biomarkers for gastrointestinal cancers. World J Gastrointest Oncol 2025; In press

Received	2025-05-30 05:22
Peer-Review Started	2025-05-30 05:22
To Make the First Decision
Return for Revision	2025-06-18 02:17
Revised	2025-07-02 18:46
Second Decision	2025-08-12 02:56
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-08-13 09:53
Articles in Press	2025-08-13 09:53
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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