Publication Name	World Journal of Gastroenterology
Manuscript ID	110112
Country	Türkiye

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Outcomes of 5-aminosalicylates withdrawal due to non-adherence in ulcerative colitis patients: A step toward evaluating intermittent therapy
Manuscript Source	Unsolicited Manuscript
All Author List	Ali Atay, Mucahit Ergul, Oguz Ozturk, Kadir C Acun, Yavuz Cagir, Muhammed B Durak and Ilhami Yuksel
Funding Agency and Grant Number
Corresponding Author	Ilhami Yuksel, Professor, Department of Gastroenterology, Faculty of Medicine, Ankara Yildirim Beyazit University, İhsan Dogramaci Cad. Bilkent, Ankara 06800, Türkiye. yukselilhami@hotmail.com
Key Words	Inflammatory bowel disease; Ulcerative colitis; 5-aminosalicylates; Treatment withdrawal; Relapse; Intermittent therapy
Core Tip	In this study, 5-aminosalicylate (5-ASA) withdrawal was observed in 3.4% of patients with ulcerative colitis (UC). Almost half of them developed a relapse. The majority of patients who experienced relapse were treated with 5-ASA monotherapy, while one-fourth of them required corticosteroids. No patients required biological agents, hospitalization, or surgery. Based on our long-term real-world data, intermittent therapy may represent a potentially safe and feasible strategy in terms of relapse risk in patients with UC. Notably, in patients who have sustained long-term clinical remission, a treatment interruption of up to one year may be considered safe.
Citation	Atay A, Ergul M, Ozturk O, Acun KC, Cagir Y, Durak MB, Yuksel I. Outcomes of 5-aminosalicylates withdrawal due to non-adherence in ulcerative colitis patients: A step toward evaluating intermittent therapy. World J Gastroenterol 2025; In press

Received	2025-05-30 06:25
Peer-Review Started	2025-05-30 06:25
To Make the First Decision
Return for Revision	2025-06-04 03:43
Revised	2025-06-14 10:40
Second Decision	2025-07-18 02:43
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-18 05:11
Articles in Press	2025-07-18 05:11
Publication Fee Transferred	2025-06-16 10:16
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Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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