Publication Name	World Journal of Orthopedics
Manuscript ID	110155
Country	China

Category	Pediatrics
Manuscript Type	Review
Article Title	Internal diseases and molecular mechanisms causing slipped capital femoral epiphysis in children
Manuscript Source	Invited Manuscript
All Author List	Yi-Fan Chen, Ke Ning, Yu-Yin Xie, Can Liu, Yi-Tong Ding, Zhong-Wen Tang, Jie Wen, Sheng Xiao and Yu-Fei Li
Funding Agency and Grant Number	Funding Agency Grant Number Science project of Hunan Provincial Healthy Commission No. 20230844
Corresponding Author	Jie Wen, Department of Pediatric Orthopedics, Hunan Provincial People’s Hospital, The First Affiliated Hospital of Hunan Normal University, No. 61 West Jiefang Road, Changsha 410013, Hunan Province, China. cashwj@qq.com
Key Words	Slipped capital femoral epiphysis; Hypothyroidism; Growth hormone abnormalities; Hypogonadism; Obesity-related hormonal imbalances
Core Tip	Slipped capital femoral epiphysis is an adolescent hip disorder causing hip pain, abnormal gait, and potential avascular necrosis. Although its exact cause is unknown, risk factors include endocrine disorders (e.g., hypothyroidism, growth hormone abnormalities), metabolic conditions (e.g., obesity, renal osteodystrophy), and genetic diseases (e.g., COL2A1 mutations). This article summarizes these associated conditions and explores potential mechanisms involving growth plate chondrocyte dysfunction, hormonal imbalances, and inflammatory/metabolic factors, aiming to support slipped capital femoral epiphysisprevention and treatment.
Citation	Chen YF, Ning K, Xie YY, Liu C, Ding YT, Tang ZW, Wen J, Xiao S, Li YF. Internal diseases and molecular mechanisms causing slipped capital femoral epiphysis in children. World J Orthop 2025; In press

Received	2025-05-30 01:59
Peer-Review Started	2025-05-30 02:00
To Make the First Decision
Return for Revision	2025-06-23 01:59
Revised	2025-07-06 10:40
Second Decision	2025-10-24 02:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-10-24 08:30
Articles in Press	2025-10-24 08:30
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-5836 (online)
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