Publication Name	World Journal of Cardiology
Manuscript ID	110163
Country	United States

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Review
Article Title	Integrative cardiovascular disease therapy: Linoleic acid restriction, enhanced external counterpulsation, and emerging nanotherapies
Manuscript Source	Unsolicited Manuscript
All Author List	Joseph Mercola
Funding Agency and Grant Number
Corresponding Author	Joseph Mercola, Researcher, /, Midwestern University, 555 31st Street, Downers Grove, IL 60515, United States. drm@mercola.com
Key Words	Cardiovascular disease; Atherosclerosis; Integrative therapy; Linoleic acid reduction; Enhanced external counterpulsation; Nanoparticle-facilitated chelation; Metabolic optimization; Residual cardiovascular risk
Core Tip	Cardiovascular disease (CVD) care still leaves a 20 % five-year major adverse cardiovascular event (MACE) risk. This review outlines an integrative, root-cause strategy combining dietary linoleic acid (LA) restriction ( < 5 g/day) to lower oxidized low-density lipoprotein (oxLDL), non-invasive enhanced external counterpulsation (EECP) to boost nitric-oxide–mediated perfusion, and plaque-targeted nanoliposomal chelation to reverse calcification. These scalable, affordable interventions collectively target oxidative stress, endothelial inflammation and plaque instability, offering a realistic roadmap to transform coronary events from commonplace to rare and potentially reshape future CVD management.
Citation	Mercola J. Integrative cardiovascular disease therapy: Linoleic acid restriction, enhanced external counterpulsation, and emerging nanotherapies. World J Cardiol 2025; In press

Received	2025-05-30 01:41
Peer-Review Started	2025-05-30 01:41
To Make the First Decision
Return for Revision	2025-06-06 03:40
Revised	2025-06-12 19:49
Second Decision	2025-07-18 02:46
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-18 07:02
Articles in Press	2025-07-18 07:02
Publication Fee Transferred	2025-06-17 17:14
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1949-8462 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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