Publication Name	World Journal of Hepatology
Manuscript ID	110185
Country	Malaysia

Category	Endocrinology & Metabolism
Manuscript Type	Review
Article Title	Liver as a metabolic sensor in gestational diabetes: Implications for offspring’s liver and diabetes risk
Manuscript Source	Invited Manuscript
All Author List	Mona Mohamed Ibrahim Abdalla and Mohammed Ismail-Khan
Funding Agency and Grant Number
Corresponding Author	Mona Mohamed Ibrahim Abdalla, MD, PhD, Department of Human Biology, School of Medicine, International Medical University, No. 126 Jln Jalil Perkasa 19, Bukit Jalil 57000, Kuala Lumpur, Malaysia. monamohamed@imu.edu.my
Key Words	Hepatokines; Liver; Metabolic sensor; Fetal metabolic imprinting; Epigenetic reprogramming; Intrauterine exposure; Insulin resistance in pregnancy
Core Tip	Gestational diabetes mellitus does not only affect maternal glucose metabolism, but it can also program lifelong metabolic vulnerabilities in the offspring. This article emphasizes the underappreciated role of the maternal liver as a metabolic sensor that detects pregnancy-related physiological stress and modulates systemic signals accordingly. When impaired by gestational diabetes mellitus, the maternal liver becomes a source of maladaptive endocrine, inflammatory, and metabolic cues that are transmitted to the fetus. These signals can reprogram fetal liver development and increase the risk of non-alcoholic fatty liver disease and type 2 diabetes mellitus in later life. Recognizing the liver’s central role in this process opens new avenues for preventive and therapeutic strategies targeting both maternal and offspring health.
Citation	Abdalla MMI, Ismail-Khan M. Liver as a metabolic sensor in gestational diabetes: Implications for offspring’s liver and diabetes risk. World J Hepatol 2025; In press

Received	2025-06-03 03:03
Peer-Review Started	2025-06-03 03:03
To Make the First Decision
Return for Revision	2025-06-23 01:40
Revised	2025-07-05 18:13
Second Decision	2025-11-06 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-07 02:26
Articles in Press	2025-11-07 02:26
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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