| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Prognostic factors and efficacy of postoperative chemotherapy in patients with gastric cancer with positive peritoneal cytology after gastrectomy
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yoichi Sugiyama, Kazuaki Tanabe, Senichiro Yanagawa, Hirofumi Tazawa, Kazuhiro Toyota, Mikihiro Kano, Toshihiro Misumi, Masayuki Shishida, Keisuke Okano, Ryuichi Hotta, Hiroshi Ota, Yasuhiro Imaoka, Toshikatsu Fukuda, Shinya Takahashi and Hideki Ohdan |
| Funding Agency and Grant Number |
|
| Corresponding Author |
Kazuaki Tanabe, Department of Perioperative and Critical Care Management, Graduate School of Biomedical and Health Science, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima 734-8551, Japan. ktanabe2@hiroshima-u.ac.jp |
| Key Words |
Gastric cancer; Peritoneal lavage cytology-positive; Chemotherapy; Prognostic factor; Treatment strategy; Cancer statistics; Survival |
| Core Tip |
This multicenter retrospective cohort study identifies key prognostic factors in cytology-positive gastric cancer patients undergoing gastrectomy. Diffuse-type histology and absence of postoperative chemotherapy were independent poor prognostic indicators. Critically, combination chemotherapy with fluoropyrimidine plus docetaxel or oxaliplatin significantly improved survival, with a 5-year survival rate of 82.4% vs 21.8% for S-1 or cisplatin-based regimens. The chemotherapy regimen was an independent predictor of overall survival. These findings highlight the importance of intensive postoperative chemotherapy in improving outcomes for this high-risk population. |
| Citation |
Sugiyama Y, Tanabe K, Yanagawa S, Tazawa H, Toyota K, Kano M, Misumi T, Shishida M, Okano K, Hotta R, Ota H, Imaoka Y, Fukuda T, Takahashi S, Ohdan H. Prognostic factors and efficacy of postoperative chemotherapy in patients with gastric cancer with positive peritoneal cytology after gastrectomy. World J Gastrointest Oncol 2025; In press |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
