Publication Name	World Journal of Clinical Oncology
Manuscript ID	110257
Country	Egypt

Category	Pathology
Manuscript Type	Basic Study
Article Title	Tight junction disruption via claudin-6 overexpression promotes invasion and recurrence in high-grade endometrial tumors
Manuscript Source	Invited Manuscript
All Author List	Noura A A Ebrahim, Tamer S Eissa, Mustafa A Hussein, Omnia Mohamed Korany and Nancy H Amin
Funding Agency and Grant Number
Corresponding Author	Noura A A Ebrahim, Assistant Professor, Consultant, MD, PhD, Post Doctoral Researcher, Postdoc, Department of Oncologic Pathology, National Cancer Institute, Cairo University, 1st Kasr Alainy Street, Cairo 11796, Al Qāhirah, Egypt. npathologist@gmail.com
Key Words	Claudin-6; High-grade endometrial carcinoma; Prognostic biomarker; Immunohistochemistry; Survival analysis; Tumor aggressiveness
Core Tip	This investigation elucidates the tumor-promoting function of claudin-6 (CLDN6) in high-grade endometrial carcinoma (HGEC). Immunohistochemical analysis of 80 clinical samples revealed a strong correlation between elevated CLDN6 expression and adverse pathological features, such as the nonendometrioid histologic subtype, extensive myometrial infiltration, lymphovascular space involvement, and regional lymph node dissemination. Multivariate statistical evaluation revealed that CLDN6 expression was an independent prognostic indicator for both disease-free survival and overall survival. Collectively, these results suggest that CLDN6 may serve as a valuable prognostic marker and a viable therapeutic target in the management of aggressive forms of endometrial cancer.
Citation	Ebrahim NAA, Eissa TS, Hussein MA, Korany OM, Amin NH. Tight junction disruption via claudin-6 overexpression promotes invasion and recurrence in high-grade endometrial tumors. World J Clin Oncol 2025; In press

Received	2025-06-03 15:56
Peer-Review Started	2025-06-03 15:57
To Make the First Decision
Return for Revision	2025-06-10 07:06
Revised	2025-06-20 23:17
Second Decision	2025-10-24 02:43
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-10-25 00:35
Articles in Press	2025-10-25 00:35
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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