Publication Name	World Journal of Orthopedics
Manuscript ID	110332
Country	China

Category	Orthopedics
Manuscript Type	Retrospective Cohort Study
Article Title	Postural correction training improves chronic pain, nerve function, and inflammation in knee osteoarthritis: A retrospective cohort study
Manuscript Source	Unsolicited Manuscript
All Author List	Qing-Qing Chen, Yang Liu, Ju-Hui Yang and Bo Yang
Funding Agency and Grant Number
Corresponding Author	Bo Yang, Associate Chief Physician, Dean, Department of Orthopedics, Haian Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, No. 55 Ninghai Middle Road, Nantong 226600, Jiangsu Province, China. yangbo_12138@163.com
Key Words	Knee osteoarthritis; Training; Pain; Inflammation; Curative effect; Influencing factor
Core Tip	This retrospective analysis demonstrated that postural correction training (PCT) combined with conventional treatment significantly improves outcomes in knee osteoarthritis (KOA) beyond pain relief. This intervention uniquely reduced neurological impairment (measured by the National Institute of Health Stroke Scale) and key inflammatory biomarkers (interleukin-1β, interleukin-6, tumor necrosis factor-α, C-reactive protein) compared to conventional treatment alone. Crucially, joint effusion, advanced Kellgren-Lawrence stage (III-IV), and > 5° flexion contracture were identified as independent risk factors for treatment failure. Conversely, PCT served as a protective factor against inefficacy. These findings position mechanical alignment correction as a disease-modifying strategy addressing neuro-inflammatory mechanisms in KOA.
Citation	Chen QQ, Liu Y, Yang JH, Yang B. Postural correction training improves chronic pain, nerve function, and inflammation in knee osteoarthritis: A retrospective cohort study. World J Orthop 2025; In press

Received	2025-06-06 12:42
Peer-Review Started	2025-06-06 12:42
To Make the First Decision
Return for Revision	2025-06-14 10:41
Revised	2025-06-21 01:34
Second Decision	2025-07-15 02:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-15 08:20
Articles in Press	2025-07-15 08:20
Publication Fee Transferred	2025-06-22 08:34
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-5836 (online)
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