Publication Name	World Journal of Methodology
Manuscript ID	110342
Country	India

Category	Medicine, General & Internal
Manuscript Type	Minireviews
Article Title	Update on hypoxic-ischemic brain injury: Prognosis and management
Manuscript Source	Invited Manuscript
All Author List	Ajaya Kumar Ayyappan Unnithan
Funding Agency and Grant Number
Corresponding Author	Ajaya Kumar Ayyappan Unnithan, Assistant Professor, Department of Neurosurgery, Azeezia Medical College Hospital, Department of Neurosurgery, Azeezia Medical College, Kerala, India. Electronic address: drajayakumara@gmail.com., Kollam 691537, Kerala, India. drajayakumara@gmail.com
Key Words	Brain hypoxia-ischemia; Cerebral autoregulation; Post-cardiac arrest syndrome; Targeted temperature management; Diffusion-weighted imaging; Neuron-specific enolase; Multimodal prognostication; Persistent vegetative state
Core Tip	The indicators of good prognosis in hypoxic-ischemic brain injury (HIBI) are: An early return of continuous and reactive electroencephalogram, low blood levels of neuron specific enolase, absence of diffusion changes in brain magnetic resonance imaging, good functional status, and Coma Remission Scale scores of 8 and more. The treatment consists of maintaining systemic perfusion, treatment of the underlying cause of the hypoxia, and prevention of ongoing brain injury. HIBI is a major cause of mortality and the outcome after survival may vary from persistent vegetative state to neuropsychiatric disabilities.
Citation	Unnithan AKA. Update on hypoxic-ischemic brain injury: Prognosis and management. World J Methodol 2025; In press

Received	2025-06-05 14:29
Peer-Review Started	2025-06-05 14:29
To Make the First Decision
Return for Revision	2025-06-17 09:22
Revised	2025-06-28 17:57
Second Decision	2025-09-22 02:45
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-22 07:31
Articles in Press	2025-09-22 07:31
Publication Fee Transferred
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Typeset the Manuscript

ISSN	2222-0682 (online)
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