Publication Name	World Journal of Experimental Medicine
Manuscript ID	110372
Country	India

Category	Dentistry, Oral Surgery & Medicine
Manuscript Type	Basic Study
Article Title	Immunohistochemical expression of epithelial mesenchymal transition proteins ZEB1 and E-cadherin in oral leukoplakia and oral squamous cell carcinoma
Manuscript Source	Invited Manuscript
All Author List	Gouri S Panchannavar and Punnya V Angadi
Funding Agency and Grant Number
Corresponding Author	Punnya V Angadi, Deputy Director, Full Professor, MD, Department of Oral and Maxillofacial Pathology, KLE VK Institute of Dental Sciences, KLE Academy of Higher Education and Research, JNMC Campus, Nehrunagar, Belagavi 580010, Karnataka, India. punnya_angadi@rediffmail.com
Key Words	Oral squamous cell carcinoma; Oral leukoplakia; Oral epithelial dysplasia; Epithelial mesenchymal transition; E-cadherin; Zinc-finger E-box-binding homeobox 1
Core Tip	The study demonstrates the presence of the epithelial-mesenchymal transition (EMT) phenomenon in oral premalignant and malignant lesions suggesting it to be an early change in carcinogenesis. The loss of E-cadherin and up-regulation of zinc-finger E-box-binding homeobox 1 from oral epithelial dysplasia to oral squamous cell carcinoma corresponds to its role in the induction of EMT and correlated to regional lymph node metastasis, thus promoting tumor progression, invasion, and metastasis. Discriminant formulas have been established to ascertain the malignant potential and to categorize instances of oral epithelial dysplasia and oral squamous cell carcinoma based on the expression of EMT markers which is not previously reported.
Citation	Panchannavar GS, Angadi PV. Immunohistochemical expression of epithelial mesenchymal transition proteins ZEB1 and E-cadherin in oral leukoplakia and oral squamous cell carcinoma. World J Exp Med 2025; In press

Received	2025-06-06 13:21
Peer-Review Started	2025-06-06 13:21
To Make the First Decision
Return for Revision	2025-06-17 09:21
Revised	2025-06-21 17:12
Second Decision	2025-09-05 02:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-05 07:42
Articles in Press	2025-09-05 07:42
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ISSN	2220-315x (online)
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