Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	110468
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Emerging non-invasive imaging biomarkers of Ki-67 in pancreatic cancer: Toward predictive precision oncology
Manuscript Source	Invited Manuscript
All Author List	Yi-Xin Wu, Rui Tian, Xiao-Wen Li, Jie-Yu Guo, Jing-Feng Tang and Ce-Fan Zhou
Funding Agency and Grant Number	Funding Agency Grant Number National Key R&D Program of China 2023YFC2507900 National Natural Science Foundation of China 32270768, 82273970, 82370715 Innovation Group Project of Hubei Province 2023AFA026 Key Cultivation Project of Hubei Province for Science and Technology 2024DJA037 National Natural Science Foundation of Hubei 2025AFA085
Corresponding Author	Ce-Fan Zhou, Professor, School of Life and Health Sciences, Institute of Biomedical Research, National “111” Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei University of Technology, No. 28 Nanli Road, Wuhan 430068, Hubei Province, China. cefan@hbut.edu.cn
Key Words	Ki-67 expression; Pancreatic cancer; Contrast-enhanced ultrasound; Imaging techniques; Clinical diagnosis
Core Tip	Ki-67 expression levels in tumor cells function as both an early predictor of treatment response and a long-term prognostic factor in cancer patients. In this study, we begin by assessing the limitations of current non-invasive imaging techniques for evaluating Ki-67 in pancreatic cancer. Subsequently, we explore more rational methodological refinements, including prospective studies and combined imaging modalities, with the objective of enhancing predictive accuracy. This discussion also highlights potential future research directions.
Citation	Wu YX, Tian R, Li XW, Guo JY, Tang JF, Zhou CF. Emerging non-invasive imaging biomarkers of Ki-67 in pancreatic cancer: Toward predictive precision oncology. World J Gastrointest Oncol 2025; In press

Received	2025-06-10 01:30
Peer-Review Started	2025-06-10 01:30
To Make the First Decision
Return for Revision	2025-06-24 09:22
Revised	2025-07-05 04:08
Second Decision	2025-09-22 02:41
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-22 09:04
Articles in Press	2025-09-22 09:04
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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