Publication Name	World Journal of Gastroenterology
Manuscript ID	110481
Country	United Kingdom

Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Skeletal muscle alterations in metabolic dysfunction-associated steatotic liver disease: A critical review of diagnostic, mechanistic, and therapeutic intersections
Manuscript Source	Unsolicited Manuscript
All Author List	Vaynika Gupta and Ashwin Krishnamoorthy
Funding Agency and Grant Number
Corresponding Author	Vaynika Gupta, College of Medicine and Health, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom. vxg381@student.bham.ac.uk
Key Words	Metabolic dysfunction-associated steatotic liver disease; Skeletal muscle alterations; Sarcopenia; Myosteatosis; Muscle metabolism; Physical activity; Glucagon-like peptide-1 receptor agonistsMetabolic dysfunction-associated steatotic liver disease; Skeletal muscle alterations; Sarcopenia; Myosteatosis; Muscle metabolism; Physical activity; Glucagon-like peptide-1 receptor agonists
Core Tip	Skeletal muscle alterations, such as sarcopenia, myosteatosis, and metabolic dysregulation, are increasingly common in pathogenesis and progression of metabolic dysfunction-associated steatotic liver disease. Underlying mechanisms, including insulin resistance, inflammation, and myokine imbalance, along with emerging biomarkers offer opportunities to study lifestyle and pharmacological interventions such as glucagon-like peptide-1 agonists. Further development must build on gaps in current literature, standardize diagnostic criteria and evaluate translational data for clinical applicability.
Citation	Gupta V, Krishnamoorthy A. Skeletal muscle alterations in metabolic dysfunction-associated steatotic liver disease: A critical review of diagnostic, mechanistic, and therapeutic intersections. World J Gastroenterol 2025; In press

Received	2025-06-10 01:27
Peer-Review Started	2025-06-10 01:27
To Make the First Decision
Return for Revision	2025-06-17 10:46
Revised	2025-06-30 03:49
Second Decision	2025-07-25 02:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-25 05:43
Articles in Press	2025-07-25 05:43
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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