Publication Name	World Journal of Diabetes
Manuscript ID	110515
Country	United States

Category	Endocrinology & Metabolism
Manuscript Type	Review
Article Title	Macrophage and inflammation in diabetes and metabolic dysfunction-associated steatotic liver disease: From mechanisms to therapeutic strategies
Manuscript Source	Invited Manuscript
All Author List	Chun-Ye Zhang, Shuai Liu and Ming Yang
Funding Agency and Grant Number
Corresponding Author	Ming Yang, Assistant Professor, PhD, Department of Surgery, University of Connecticut, School of Medicine, 263 Farmington Avenue, Farmington, CT 06030, United States. minyang@uchc.edu
Key Words	Macrophage; Inflammation; Diabetes; Metabolic dysfunction-associated steatotic liver disease; Mechanism; Cytokines; Therapy
Core Tip	Macrophages are an important cellular component that regulates metabolic disorders, including metabolic dysfunction-associated steatotic liver disease (MASLD) and type 2 diabetes (T2D). Macrophage-derived cytokines, chemokines, and metabolic products contribute to metabolic inflammation and insulin resistance, immune cell infiltration, and tissue injury. The phenotype and function of macrophages are important factors for evaluating the efficacy of MASLD and T2D treatments. Clinical trials are ongoing to dissect the roles of macrophages and test macrophage-targeted therapies in MASLD, T2D, and other related metabolic disorders.
Citation	Zhang CY, Liu S, Yang M. Macrophage and inflammation in diabetes and metabolic dysfunction-associated steatotic liver disease: From mechanisms to therapeutic strategies. World J Diabetes 2025; In press

Received	2025-06-09 07:28
Peer-Review Started	2025-06-10 00:08
To Make the First Decision
Return for Revision	2025-06-24 09:40
Revised	2025-07-08 05:01
Second Decision	2025-08-19 02:48
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-08-26 08:23
Articles in Press	2025-08-26 08:23
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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