Publication Name	World Journal of Critical Care Medicine
Manuscript ID	110552
Country	Australia

Category	Critical Care Medicine
Manuscript Type	Opinion Review
Article Title	Continuous renal replacement therapy in acute liver failure
Manuscript Source	Invited Manuscript
All Author List	Caleb Fisher and Stephen Warrillow
Funding Agency and Grant Number
Corresponding Author	Stephen Warrillow, Associate Professor, FRACP, PhD, Department of Intensive Care, Austin Health, 145 Studley Road, Heidelberg 3084, Victoria, Australia. stephen.warrillow@austin.org.au
Key Words	Acute liver failure; Continuous renal replacement therapy; Hyperammonaemia; Cerebral oedema; Acute liver injury
Core Tip	The early initiation of continuous renal replacement therapy in patients admitted to the intensive care unit with acute liver failure is safe and provides a range of benefits that are likely neuroprotective. These include control of hyperammonaemia, prevention of fever, control of acidaemia, control of fluid balance and control of electrolyte derangement. Continuous renal replacement therapy can be started in all acute liver failure patients intubated for hepatic encephalopathy and should not be delayed until evidence of renal failure becomes apparent.
Citation	Fisher C, Warrillow S. Continuous renal replacement therapy in acute liver failure. World J Crit Care Med 2025; In press

Received	2025-06-10 10:41
Peer-Review Started	2025-06-10 10:42
To Make the First Decision
Return for Revision	2025-08-06 10:59
Revised	2025-08-19 13:14
Second Decision	2025-11-14 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-14 13:20
Articles in Press	2025-11-14 13:20
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3141(online)
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