Publication Name	World Journal of Gastroenterology
Manuscript ID	110573
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Diagnostic accuracy of dual-layer spectral computed tomography virtual monoenergetic imaging with multiplanar reformation for T-staging of colorectal cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Fei-Xiang Chen, Ke-Ke Jiang, Jian-Feng Zhu, Mei-Rong Wang, Xiao-Le Fan, Ju-Shun Yang and Bo-Sheng He
Funding Agency and Grant Number	Funding Agency Grant Number Jiangsu Province 333 Talent Key Industry Field Talent Project [2022]21 Key Scientific Research Program of Jiangsu Provincial Health Committee ZD2021059 Nantong Key Laboratory Project [2020]163 The Project of Nantong City Health Committee MS2023027 Young Medical Talents Fund of Health and Family Planning Commission of Nantong QA2019006 Young Medical Talents Fund of Health and Family Planning Commission of Nantong QNZ2023027
Corresponding Author	Bo-Sheng He, PhD, Department of Radiology, Nantong First People’s Hospital, Affiliated Hospital 2 of Nantong University, No. 666 Shengli Road, Nantong 226001, Jiangsu Province, China. boshenghe@126.com
Key Words	Colorectal cancer; Dual-layer spectral computed tomography; Multiplanar reformation; Peritumoral fat stranding; T staging; Virtual monoenergetic images
Core Tip	Accurate preoperative T staging is critical for guiding individualized therapeutic strategies in colorectal cancer (CRC). However, conventional computed tomography demonstrates limited diagnostic performance, with reported accuracies ranging from 60.6% to 89%. This study demonstrated that low-energy (40-50 keV) virtual monoenergetic images (VMIs), when combined with multiplanar reformation (MPR), could substantially improve T staging accuracy to as high as 94.27%. While peritumoral fat stranding further enhanced staging accuracy on polyenergetic images, MPR alone achieved an accuracy of 77.07%. These findings supported the incorporation of low-keV VMIs and MPR into routine preoperative imaging protocols to optimize CRC staging and management.
Citation	Chen FX, Jiang KK, Zhu JF, Wang MR, Fan XL, Yang JS, He BS. Diagnostic accuracy of dual-layer spectral computed tomography virtual monoenergetic imaging with multiplanar reformation for T-staging of colorectal cancer. World J Gastroenterol 2025; In press

Received	2025-06-11 05:49
Peer-Review Started	2025-06-11 05:49
To Make the First Decision
Return for Revision	2025-06-23 07:53
Revised	2025-07-06 07:46
Second Decision	2025-07-28 02:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-28 06:16
Articles in Press	2025-07-28 06:16
Publication Fee Transferred	2025-07-08 00:58
Edit the Manuscript by Language Editor	2025-08-02 18:36
Typeset the Manuscript	2025-08-14 09:15

ISSN	1007-9327 (print) and 2219-2840 (online)
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