Publication Name	World Journal of Gastroenterology
Manuscript ID	110582
Country	China

Category	Anesthesiology
Manuscript Type	Retrospective Cohort Study
Article Title	Efficacy and safety of different doses of dexmedetomidine on gastrointestinal function recovery after laparoscopic colorectal surgery
Manuscript Source	Unsolicited Manuscript
All Author List	Ying Chen, Wen-Lu Tang, Chun-Tian Li, Yu Zhao, Bing Li, Lian-Ming Liao, Tian-Hua Lin and Liang-Cheng Zhang
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Foundation of Fujian Province No. 2021J011438
Corresponding Author	Liang-Cheng Zhang, Department of Anaesthesiology, Fujian Medical University Union Hospital, No. 29 Xin-Quan Road, Fuzhou 350000, Fujian Province, China. zhanglc@fjmu.edu.cn
Key Words	Dexmedetomidine; Laparoscopic colorectal surgery; Gastrointestinal function; Adverse event; Retrospective study
Core Tip	Both low-dose and high-dose dexmedetomidine enhance gastrointestinal recovery after laparoscopic colorectal surgery, significantly shortening time to first flatus, defecation, and oral intake vs controls. No dose-dependent benefit observed: High-dose dexmedetomidine (1.0 μg/kg + 0.5 μg/kg/hour) did not further accelerate gastrointestinal recovery compared to low-dose (0.5 μg/kg + 0.2 μg/kg/hour). Low-dose regimen demonstrated superior safety: High-dose dexmedetomidine significantly increased intraoperative bradycardia risk (19.15% vs 8.19% in controls, P < 0.05). Reduced opioid/sedative requirements: Dexmedetomidine groups required less propofol and remifentanil than controls, potentially mitigating opioid-induced gastrointestinal dysfunction. Clinical recommendation: Low-dose dexmedetomidine is optimal for enhancing gastrointestinal recovery while minimizing cardiovascular risks.
Citation	Chen Y, Tang WL, Li CT, Zhao Y, Li B, Liao LM, Lin TH, Zhang LC. Efficacy and safety of different doses of dexmedetomidine on gastrointestinal function recovery after laparoscopic colorectal surgery. World J Gastroenterol 2025; In press

Received	2025-06-13 09:17
Peer-Review Started	2025-06-13 09:17
To Make the First Decision
Return for Revision	2025-06-24 11:40
Revised	2025-07-08 08:05
Second Decision	2025-07-31 02:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-31 03:05
Articles in Press	2025-07-31 03:05
Publication Fee Transferred	2025-07-09 15:02
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-08-05 08:58

ISSN	1007-9327 (print) and 2219-2840 (online)
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