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Publication Name World Journal of Gastroenterology
Manuscript ID 110582
Country China
Category Anesthesiology
Manuscript Type Retrospective Cohort Study
Article Title Efficacy and safety of different doses of dexmedetomidine on gastrointestinal function recovery after laparoscopic colorectal surgery
Manuscript Source Unsolicited Manuscript
All Author List Ying Chen, Wen-Lu Tang, Chun-Tian Li, Yu Zhao, Bing Li, Lian-Ming Liao, Tian-Hua Lin and Liang-Cheng Zhang
Funding Agency and Grant Number
Funding Agency Grant Number
Natural Science Foundation of Fujian Province No. 2021J011438
Corresponding Author Liang-Cheng Zhang, Department of Anaesthesiology, Fujian Medical University Union Hospital, No. 29 Xin-Quan Road, Fuzhou 350000, Fujian Province, China. zhanglc@fjmu.edu.cn
Key Words Dexmedetomidine; Laparoscopic colorectal surgery; Gastrointestinal function; Adverse event; Retrospective study
Core Tip Both low-dose and high-dose dexmedetomidine enhance gastrointestinal recovery after laparoscopic colorectal surgery, significantly shortening time to first flatus, defecation, and oral intake vs controls. No dose-dependent benefit observed: High-dose dexmedetomidine (1.0 μg/kg + 0.5 μg/kg/hour) did not further accelerate gastrointestinal recovery compared to low-dose (0.5 μg/kg + 0.2 μg/kg/hour). Low-dose regimen demonstrated superior safety: High-dose dexmedetomidine significantly increased intraoperative bradycardia risk (19.15% vs 8.19% in controls, P < 0.05). Reduced opioid/sedative requirements: Dexmedetomidine groups required less propofol and remifentanil than controls, potentially mitigating opioid-induced gastrointestinal dysfunction. Clinical recommendation: Low-dose dexmedetomidine is optimal for enhancing gastrointestinal recovery while minimizing cardiovascular risks.
Citation <p>Chen Y, Tang WL, Li CT, Zhao Y, Li B, Liao LM, Lin TH, Zhang LC. Efficacy and safety of different doses of dexmedetomidine on gastrointestinal function recovery after laparoscopic colorectal surgery. <i>World J Gastroenterol</i> 2025; 31(31): 110582</p>
Received
2025-06-13 09:17
Peer-Review Started
2025-06-13 09:17
To Make the First Decision
Return for Revision
2025-06-24 11:40
Revised
2025-07-08 08:05
Second Decision
2025-07-31 02:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief
2025-07-31 03:05
Articles in Press
2025-07-31 03:05
Publication Fee Transferred
2025-07-09 15:02
Edit the Manuscript by Language Editor
Typeset the Manuscript
2025-08-05 08:58
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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