Publication Name	World Journal of Diabetes
Manuscript ID	110639
Country	China

Category	Endocrinology & Metabolism
Manuscript Type	Meta-Analysis
Article Title	Trends in baseline blood lipid levels in randomized placebo-controlled trials of overweight or obesity from 1990 to 2024
Manuscript Source	Unsolicited Manuscript
All Author List	Ya-Qi Wang, Quan-Zhou Xiao, Zhen-Ming Zhang and Yan Yang
Funding Agency and Grant Number
Corresponding Author	Yan Yang, Metabolic Syndrome Research Center, The Second Xiangya Hospital of Central South University, No. 139 Renmin Middle Road, Changsha 410000, Hunan Province, China. 228201015@csu.edu.cn
Key Words	Overweight; Obesity; Dyslipidemia; Lipid profile; Triglycerides; Cholesterol
Core Tip	This global meta-analysis of 866 randomized trials (n = 3300) reveals significant improvements in lipid profiles among overweight/obese individuals over three decades, with triglycerides, total cholesterol and low-density lipoprotein-cholesterol declining while high-density lipoprotein-cholesterol increased. Notably, pharmacological interventions showed the most pronounced benefits. These findings highlight that despite rising obesity rates, concerted public health efforts and therapeutic advances have successfully mitigated dyslipidemia risks in this high-risk population, offering crucial insights for clinical practice and health policy.
Citation	Wang YQ, Xiao QZ, Zhang ZM, Yang Y. Trends in baseline blood lipid levels in randomized placebo-controlled trials of overweight or obesity from 1990 to 2024. World J Diabetes 2025; In press

Received	2025-06-11 02:32
Peer-Review Started	2025-06-11 08:31
To Make the First Decision
Return for Revision	2025-06-24 09:42
Revised	2025-07-23 06:11
Second Decision	2025-08-18 02:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-08-27 09:25
Articles in Press	2025-08-27 09:25
Publication Fee Transferred	2025-07-29 13:17
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com