Publication Name	World Journal of Stem Cells
Manuscript ID	110663
Country	China

Category	Emergency Medicine
Manuscript Type	Randomized Controlled Trial
Article Title	Combined mesenchymal and neural stem cell therapy enhances neurological recovery in cerebral infarction
Manuscript Source	Unsolicited Manuscript
All Author List	Ting Yang, Hui Yu, Dong Han and Zheng Xie
Funding Agency and Grant Number
Corresponding Author	Hui Yu, Department of Emergency, Affiliated Hospital of Jiangnan University, No. 1000 Hefeng Road, Binhu District, Wuxi 214000, Jiangsu Province, China. yuhuiyh56@163.com
Key Words	Acute cerebral infarction; Neural stem cells; Mesenchymal stem cells; Vascular endothelial growth factor; Basic fibroblast growth factor; Neurological function
Core Tip	Combination therapy with neural stem cell (NSC) and mesenchymal stem cell (MSC) promotes neurological recovery in patients with acute cerebral infarction (ACI) by modulating vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) expression, thereby enhancing cerebral perfusion, daily living capacity, and neurological function scores. This study validated the efficacy and safety of NSC/MSC stem cell combination therapy, and systematically elucidated the mechanistic roles of VEGF and bFGF in the NSC-MSC-mediated treatment of ACI. These findings further demonstrate the central regulatory roles of VEGF and bFGF in angiogenesis and neural repair, thereby advancing the application of precision medicine in ACI treatment, and providing a robust theoretical foundation and future directions for clinical translation.
Citation	Yang T, Yu H, Han D, Xie Z. Combined mesenchymal and neural stem cell therapy enhances neurological recovery in cerebral infarction. World J Stem Cells 2025; In press

Received	2025-06-13 09:48
Peer-Review Started	2025-06-13 09:49
To Make the First Decision
Return for Revision	2025-07-08 06:39
Revised	2025-07-22 06:35
Second Decision	2025-08-28 01:07
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-04 10:12
Articles in Press	2025-09-04 10:12
Publication Fee Transferred	2025-07-29 03:26
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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